β-内酰胺类抗菌药物致药物热的研究

Study on the Drug Fever Caused by β-amide Antibiotics

目的分析β-内酰胺类抗菌药物致药物热的临床表现及诊治方法,为临床抗感染治疗中及时准确判断药物热提供参考。方法对2014年1月—2015年12月宁波地区4家三甲医院发生的β-内酰胺类抗菌药物致药物热的用药情况、临床表现、辅助检查等进行统计分析。结果β-内酰胺类抗菌药物致药物热的病例共41例,其中哌拉西林他唑巴坦钠居第1位18例(43.9%),其次为头孢曲松6例(14.6%),头孢地嗪5例(12.1%)。11例仅有发热表现(26.8%),其余30例伴有不同的临床表现。所有患者停药后体温恢复正常。结论临床药师应利用自己的专业优势,协助临床医师尽早诊治药物热。

OBJECTIVE To analyze the clinical manifestations and the diagnosis treatments of drug fever caused by β-amide antibiotics, and to provide reference for the timely and accurate judgment and anti infective therapy of drug fever. METHODS Collected the case of drug fever caused by β-amide antibiotics in four third-grade class-A hospitas from January 2014 to December 2015, analyzed the drug situation, clinical manifestation, auxiliary examination and so on. RESULTS Forty-one cases of drug fever caused by beta lactam antibacterial, the most of drug fever caused by piperacillin hetazobactam sodium, 18 cases（43.9%）, followed by ceftriaxone in 6 cases（14.6%）, 5 cases of cefodizime（12.1%）. Eleven cases with only fever performance（26.8%）, the remaining 30 cases accompanied by a variety of clinical manifestations. Forty cases recovered to normal after stopping the drug. CONCLUSION Clinical pharmacists should make use of their professional advantages to assist clinicians in the early diagnosis and treatment of drug fever.