PLGA微球的修饰及其应用

Decoration and Application of PLGA Microspheres

微球作为新型的药物载体系统已广泛用于临床研究,高分子化合物材料聚乳酸-羟基乙酸(pdy lactic-co-glycolic acid,PLGA)因其良好的生物相容性和生物可降解性备受关注。近年来,PLGA微球的研究一直是热门,针对其释放缺陷出现了很多复合修饰方法,主要包括环糊精、壳聚糖、聚乳酸、明胶、泊洛沙姆、聚乙烯亚胺等高分子材料的联用、针对末端基团进行化学修饰以及制备成核壳型微球,在保证包封率的情况下大大降低突释,改善药物释放曲线,从而在药物传递、基因治疗、影像诊断、组织工程等领域得到了广泛的应用。

Microspheres as novel drug delivery carriers have been widely used in clinical study, and poly lactic-co-glycolic acid（PLGA） has been one of the most attractive polymeric candidates used to fabricate devices for drug delivery due to the biocompatible and biodegradable characteristics. In recent years, in order to figure out the defects during the drug release, polymeric combination and chemical modification has been extensively studied. And the design of double-walled microspheres also has been investigated. Moreover, encapsulation efficiency and the release profiles can be improved by different modification methods. And it is extensively used in drug deliver, gene therapy and imaging diagnosis, especially in the fields of tissue engineering.