期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

远端缺血处理心脏保护作用的研究进展

下载PDF
导出
摘要 1986年,Murry等首次发现,在心脏长时间缺血前,先经过4次5 min短暂的非致命性缺血处理,可以有效地保护心脏,提升对随后长时间致命性缺血的耐受能力,并将这种内源性保护机制称为心肌缺血预处理（ischemic preconditioning,IPC）。
作者 夏中元 刘菊英 史若诗
机构地区 武汉大学人民医院麻醉科 湖北省十堰市太和医院麻醉科
出处 《广东医学》 CAS 北大核心 2016年第11期1726-1728,共3页 Guangdong Medical Journal
基金 国家自然科学基金资助项目(编号:81171783)
关键词 心脏保护作用 心肌缺血预处理 心肌保护 内源性保护机制 左旋支 心肌梗死面积 心肌细胞 信号通路 大鼠 氧化应激反应
分类号 R542.2 [医药卫生—心血管疾病]
  • 相关文献

参考文献25

  • 1Murry CE, Jennings RB, Reimer KA. Preconditioning with ische- mia: a delay of lethal cell injury in ischemic myocardium[J]. Cir- culation, 1986, 74(5): 1124-1136.
  • 2Przyklenk K, Bauer B, Ovize M, et al. Regional ischemic 'precon- ditioning' protects remote virgin myocardium from subsequent sus- tained coronary occlusion [ J ]. Circulation, 1993, 87 ( 3 ) : 893 - 899.
  • 3Kerendi F, Kin H, Halkos ME, et al. Brief renal ischemia and reperfusion applied before coronary artery reperfusion reduces myo- cardial infarct size via endogenous activation of adenosine receptors [J]. Basic Res Cardiol, 2005, 100(5) : 404 -412.
  • 4Kharbanda RK. Transient limb ischemia induces remote ischemic preconditioning in vivo [ J ]. Circulation, 2002, 106 ( 23 ) : 2881 - 2883.
  • 5Sloth AD, Sehmidt MR, Munk K, et al. Improved long -term clinical outcomes in patients with ST - elevation myocardial infarc- tion undergoing remote ischaemic conditioning as an adjunct to pri- mary percntaneous coronary intervention[ J]. Eur Heart J, 2014, 35(3) : 168 -175.
  • 6Kharbanda RK, Peters M, Walton B, et al. Ischemic precondi- tioning prevents endothelial injury and systemic nentrophil activa- tion during ischemia- reperfusion in humans in vivo[J]. Circula- tion, 2001, 103(12): 1624-1630.
  • 7Schmidt MR, Smerup M, Konstantinov IE, et al. Intermittent pe- ripheral tissue ischemia during coronary ischemia reduces myocar- dial infarction through a KATP - dependent mechanism : first dem- onstration of remote ischemic pereonditioning [J].Am J Physiol Heart Circ Physiol, 2007, 292(4) : H1883 - H1890.
  • 8Rohailla S, Clarizia N, Sourour M, et al. Acute, delayed and chronic remote ischemic conditioning is associated with downregu- lation of mTOR and enhanced autophagy signaling[ J]. PLoS One, 2014, 9(10) : e111291.
  • 9Redington KL, Disenhouse T, Strantzas SC, et al. Remote cardio- protection by direct peripheral nerve stimulation and topical capsai- cin is mediated by circulating humoral factors[J]. Basic Res Car- dial, 2012, 107(2) : 241.
  • 10Konstantinov IE, Li J, Cheung MM, et al. Remote ischemic pre-conditioning of the recipient reduces myocardial ischemia reperfusion injury of the deuervated donor heart via a Katp channel - dependent mechanism[ J]. Transplantation, 2005, 79(12) : 1691 - 1695.

二级参考文献79

  • 1Hausenloy DJ, Yellon DM. The evolving story of "conditioning" to protect against acute myocardial ischaemia-reperfusion injury. Heart, 2007, 93(6): 649-651.
  • 2Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation, 1986, 74 (5) : 1124-1136.
  • 3Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol, 2003, 285 (2) : H579-588.
  • 4Przyklenk K, Bauer B, Ovize M, et al. Regional ischemic 'precon- ditioning' protects remote virgin myocardium from subsequent sus- tained coronary occlusion. Circulation, 1993, 87 ( 3 ) : 893-899.
  • 5Gho BC, Schoemaker RG, van den Doel MA, et al. Myocardial protection by briefischemia in noncardiac tissue. Circulation, 1996, 94(9) : 2193-2200.
  • 6Pell T J, Baxter GF, Yellon DM, et al. Renal ischemia preconditions myocardium: role of adenosine receptors and ATP-sensitive potas-sium channels. Am J Physiol, 1998, 275 ( 5 Pt 2) : H 1542-1547.
  • 7Kharbanda RK, Mortensen UM, White PA, et al. Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation, 2002, 106 (23) : 2881-2883.
  • 8Bushati N, Cohen SM. microRNA functions. Annu Rev Cell Dev Biol, 2007, 23 ( 1 ) : 175-205.
  • 9Chang TC, Mcndell JT. microRNAs in vertebrate physiology and hu- man disease. Annu Rev Genomics Hum Genet, 2007, 8: 215-239.
  • 10Yin C, Salloum FN, Kukreja RC. A novel role ofmicroRNA in late preconditioning: upregulation of endothelial nitric oxide synthase and heat shock protein 70. Circ Res, 2009, 104 (5) : 572-575.

共引文献26

广东医学
2016年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部