抗病毒药他立韦林的合成

Synthesis of Taribavirin

以1,2,4-三氮唑-3-羧酸甲酯为原料合成3-氰基-1,2,4-三氮唑,再与1,2,3,5-四乙酰基-D-核糖经烷基化和氰基氨解两步反应制备抗病毒药他立韦林(Taribavirin),收率59.9%。

1,2,4-triazole-3-carboxylate was synthesized from 3-cyano-1,2,4-triazole, and then with 1,2,3,5-tetraacetyl-D- ribose by alkylation and aminolysis established antiviral Taribavirin, yield 59.9 %.