基质金属蛋白酶-9基因多态性与脑梗死相关性的Meta分析

Matrix metalloproteinase-9 gene polymorphism and cerebral infarction:A Meta-analysis

目的评价基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)基因-1562C>T多态性与脑梗死发病的相关性。方法对2015年10月前公开发表的关于脑梗死MMP-9基因-1562C>T多态性的病例对照研究进行Meta分析。结果共纳入12个病例对照研究。Meta分析结果表明,MMP-9基因-1562C>T多态性与脑梗死的发病相关,具有显著的统计学意义(显性遗传模型:OR=1.29,95%CI:1.12-1.48,P<0.01;隐性遗传模型:OR=2.20,95%CI:1.55-3.12,P<0.01)。敏感性分析显示结果稳定。倒漏斗图及Egger回归分析提示不存在发表性偏倚。结论 MMP-9基因-1562C>T多态性与脑梗死发病相关,可能是脑梗死发病的危险因素。

Objective To evaluate the relationship between MMP-9 gene -1562C〉T polymorphism and susceptibility to ce- rebral infarction. Methods Meta-analysis of case-control studies on the association between MMP-9 gene -1562C〉T polymorphism and susceptibility to cerebral infarction published up to October 2015. Results 12 case-control studies were selected. Meta-analysis results showed that the significant association between MMP-9 gene -1562C〉T and cerebral infarction was found under the dominant （OR= 1.29, 95% CI ： 1.12-1.48, P〈0.01 ） and recessive model （OR=2.20, 95% CI ： 1.55-3.12, P〈0.01 ）. Sensitivity analysis indicated the results were stable. No statistical evidence of publication bias existed among studies, reflected by the visual inspection of funnel plot and Egger＇ s regression test. Conclusion The＇ results suggested that MMP-9 gene -1562C〉T polymorphism was significantly associated with susceptibility to cerebral infarction. It maybe is the risk factor of cerebral infarction.