摘要
Adipose-derived mesenchymal stem cells （ADSCs） can be largely and easily obtained from a wide range of sources. Moreover, they have self-renewal ability, multi-differentiation potential, and an important role in immune regulation. They can secrete a variety of cytokines to regulate the in vivo micro-environment. Therefore, ADSCs are the ideal seed ceils for stem ceils application. This paper reviews the location, isolation, surface markers, proliferation, differentiation and other biological characteristics of ADSCs, as well as their secretory function and relative researches. ADSCs are expected to become excellent seed cells for cell therapy and tissue engineering through in-depth studies.
脂肪间充质干细胞(ADSCs)来源广泛,取材方便,易于获得大量细胞。其具有自我更新能力、多分化潜能和强大的免疫调节能力,同时能够分泌多种细胞因子,调节机体微环境,是目前干细胞应用的理想种子细胞。该文从ADSCs的定位、分离、表面标记物、增殖分化能力等方面阐述了ADSCs生物学特性,同时对ADSCs的分泌功能及分泌功能研究情况进行综述。以此为理论基础通过对ADSCs的深入研究,使其有望成为细胞治疗和组织工程应用的优秀种子细胞。
基金
Supported by The Fund from the Endangered Species Import and Export Management Office of the People’s Republic of China for the Management and Research of Endangered Wild Animals(201441314404)~~
