纳米颗粒的细胞摄取机制及其影响因素的研究

Research of the cellular uptake mechanism of nanoparticles and its influencing factors

由于纳米材料具有独特的性能优势,近年来纳米颗粒在临床诊断、药物载体、基因转染、组织工程、细胞示踪等方面被广泛地应用。研究纳米颗粒穿透细胞膜进入细胞内的过程以及相关的摄取机制,将有助于了解纳米材料对机体和器官的影响和作用机理,评价其对生物体潜在的危害性,这为纳米材料更安全有效地应用于生物医学领域提供了重要依据。本文将对细胞摄取纳米颗粒有关方面的近期研究作一综述。

Due to their special properties, nanoparticles have been widely used in clinical diagnosis, drug delievery, gene transfec- tion, tissue engineering and cell tracking. A detailed understanding of the process and mechanisms underlying the uptake of nanoparti- cles is important for exploring the effects and action mechanisms of nanomaterials on the biological systems and evaluating their potential harm to organisms, which will provide insight about their biological safety. This article reviewed the most recent development in the celluar uptake of nanoparticles.