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脑死亡器官捐献供肾的保护研究 被引量:2

Research Progress on Kidney Protection of Donation After Brain Death
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摘要 肾移植是治疗各种终末期肾病的有效手段。临床证实,应用脑死亡捐献(DBD)供肾移植的疗效比活体供肾差。重视对在体和离体DBD供肾的保护,减轻其热缺血、冷灌注、冷储存和再灌注损伤,改善DBD供肾活力,是研究的热点。本文主要综述DBD供肾的保护研究。 Renal transplantation is an effective method for a variety of end-stage renal disease treatment.It is known that the clinical outcome in kidney transplantation from living donors is superior to that for transplantation from brain dead donors(DBD).Effective measures should be adopted to reduce inflammation,warm/cold ischemia injury,and ischemia-reperfusion injury,in order to improve the DBD kidneys quality.We reviewed the current protective research of DBD kidneys.
出处 《武汉大学学报(医学版)》 CAS 2016年第4期586-591,611,共7页 Medical Journal of Wuhan University
关键词 脑死亡器官捐献 肾移植 器官保存 Donation After Brain Death Renal Transplantation Organ Preservation
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参考文献73

  • 1Chinese Society of Organ Transplantation,Chinese Medical Association.National guidelines for donation after cardiac death in China[J].Hepatobiliary Pancreat Dis Int,2013,12(3):234-238.
  • 2Terasaki PI,Cecka JM,Gjertson DW,et al.High survival rates of kidney transplants from spousal and living unrelated donors[J].N Engl J Med,1995,333(6):333-336.
  • 3Chen EP,Bittner HB,Kendall SW,et al.Hormonal and hemodynamic changes in a validated animal model of brain death[J].Crit Care Med,1996,24(8):1 352-1 359.
  • 4Powner DJ,Boccalandro C,Alp MS,et al.Endocrine failure after traumatic brain injury in adults[J].Neurocrit Care,2006,5(1):61-70.
  • 5Bouma HR,Ploeg RJ,Schuurs TA.Signal transduction pathways involved in brain death-induced renal injury[J].Am J Transplant,2009,9(5):989-997.
  • 6Schuurs TA,Gerbens F,van der Hoeven JA,et al.Distinct transcriptional changes in donor kidneys upon brain death induction in rats:insights in the processes of brain death[J].Am J Transplant,2004,4(12):1 972-1 981.
  • 7Novitzky D,Cooper DK,Morrell D,et al.Change from aerobic to anaerobic metabolism after brain death,and reversal following triiodothyronine therapy[J].Transplantation,1988,45(1):32-36.
  • 8Perez LS,Otero HJ,Vazquez MN,et al.Brain death effects on catecholamine levels and subsequent cardiac damage assessed in organ donors[J].J Heart Lung Transplant,2009,28(8):815-820.
  • 9Martikainen TJ,Kurola J,Karja V,et al.Vasopressor agents after experimental brain death:effects of dopamine and vasopressin on vitality of the small gut[J].Transplant Proc,2010,42(7):2 449-2 456.
  • 10Takada M,Nadeau KC,Hancock WW,et al.Effects of explosive brain death on cytokine activation of peripheral organs in the rat[J].Transplantation,1998,65(12):1 533-1 542.

二级参考文献35

  • 1Kwiatkowski A, Wszola M, Kosieradzki M, et al. Machine perfusion preservation improves renal aHograft survival EJ]. Am J Transplant, 2007, 7(8) : 1942-1947.
  • 2Polyak MM, Arrington BO, Stubenbord WT, et al. The influence of pulsatile preservation on renal transplantation in the 1990s[J3. Transplantation, 2000, 69(2):249-258.
  • 3Moers C, Smits JM, Maathuis MH, eta!. Machine perfusion or cold storage in decease&donor kidney transplantation~J~. N Engl J Med, 2009, 360(1):7-19.
  • 4Treckmann J, Moers C, Smits JM, et al. Machine perfusion versus cold storage for preservation of kidneys from expanded criteria donors after brain death[J]. Transplant Int, 2011, 24 (6) :548-554.
  • 5Jochmans I, Moers C, Smits JM, et al. Machine perfusion versus cold storage for the preservation of kidneys donated after cardiac death: a multicenter, randomized, controlled trial[J]. Ann Surg, 2010, 252(5):756-764.
  • 6Moers C, Pirenne J, Paul A, et al. Machine perfusion or cold storage in deceased-donor kidney transplantation[J]. N Engl J Med, 2012, 366(8):770-771.
  • 7HosgoodSA, Nicholson HF, Nicholson ML. Oxygenated kidney preservation techniques[J]. Transplantation, 2012, 93 (5) :455-459.
  • 8Legrand M, Mik EG, Johannes T, et al. Renal hypoxia and dysoxia after reperfusion of the ischemic kidney[J]. Mol Med, 2008, 14(7-8) ~502-516.
  • 9Mitchell T, Saba H, Laakman J, et al. Role of mitochondrial- derived oxidants in renal tubular cell cold-storage injury[J]. Free Radic Biol Med, 2010, 49(8):1273-1282.
  • 10Lee CY, Jain S, Duncan HM, et al. Survival transplantation of preserved non-heart-beating donor rat livers: preservation by hypothermic machine perfusion[J]. Transplantation, 2003, 76(10) : 1432 1436.

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