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右美托咪定肺保护的研究进展 被引量：12

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摘要 右美托咪定（dexmedetomidine,DEX）是一种新型的高选择性α2肾上腺素能受体（α2-adrenergic receptor,α2-AR）激动剂,具有镇静、镇痛、抗交感、抗氧化应激、抗炎、利尿等作用,其选择性强、半衰期短,有利于围麻醉期患者血流动力学的稳定,且副作用较少。近年来,随着对DEX大量深入的研究表明DEX可以通过多种途径对重要脏器发挥保护作用-（[1]）。本文主要对其在肺保护作用方面进行综述。1右美托咪定的生理作用及相关机制DEX自1999年从美国上市以来,
作者 周家龙 梁启胜
机构地区 蚌埠医学院第一附属医院麻醉科
出处 《中华全科医学》 2016年第8期1386-1388,共3页 Chinese Journal of General Practice
基金 安徽省蚌埠医学院研究生科研创新计划项目(Byycx1429)
关键词 右美托咪定 肺保护 作用机制
分类号 R971.2 [医药卫生—药品]
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参考文献28

  • 1Xianbao L, Hong Z, Xu Z, et al. Dexmedetomidine reduced cytokine release during postpartum bleeding-induced multiple organ dysfunction syndrome in rats[ J]. Mediators Inflamm,2013 ,627831:7.
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  • 4Funai Y, Pickering AE, Uta D, et al. Systemic dexmedetomidine aug- ments inhibitory synaptic transmission in the superficial dorsal horn through activation of descending patch-damp analysis of analgesic (3) :617-628. noradrenergic control: an in vivo mechanisms [ J ]. Pain, 2014, 155.
  • 5Li SS, Zhang WS, Ji D, et ai. Involvement of spinal microglia and inter- leukin-18 in the anti-nociceptive effect of dexmedetomidine in rats subjected to CCI[ J ]. Neurosci Lett ,2014,560:21-25.
  • 6Fan QQ,Li L,Wang WT,et al. Activation of eL2 adrenoceptors inhibi- ted NMDA receptor-mediated nociceptive transmission in spinal dorsal horn of mice with inflammatory pain [ J ]. Neuropharmacology, 2014, 77 : 185-192.
  • 7Seyrek M, Halici Z, ildiz O, et al. interaction between dexmedetomi- dine and c-adrenergic receptors : emphasis on vascular actions [ J ]. J Cardiothorac Vasc Anesth,2011,25 ( 5 ) :856-862.
  • 8Xie C, Wang Z, Tang J, et al. The effect of dexmedetomidine post-treat- ment on the inflammatory response of astrocyte induced by lipopolysac- charide[ J]. Cell Biochem Biophys ,2015 ,71 (1) :407-412.
  • 9王冰舒,余剑波,王方,张丽,张杨,李士强.右美托咪定对悬雍垂腭咽成形术患者拔管期应激反应的影响[J].中华耳鼻咽喉头颈外科杂志,2012,47(6):498-501. 被引量：8
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二级参考文献41

  • 1洪方晓,李树人.异丙酚对大鼠缺氧性肺血管收缩反应的影响[J].中华麻醉学杂志,2004,24(12):909-912. 被引量：9
  • 2阮骆阳,林春水,刘莹莹,古妙宁.利多卡因对失血性休克兔肺损伤的保护作用[J].南方医科大学学报,2007,27(4):543-545. 被引量：2
  • 3Halbertsma F J, Vaneker M, Scheffer G J, et al. Cytokines and biotrauma in ventilator-induced lung injury: a critical review of the literature[J]. Neth J Med, 2005, 63(10): 382-92.
  • 4Taniguchi T, Kidani Y, Kanakura H, et al. Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats [J]. Crit Care Med, 2004, 32(6): 1322-6.
  • 5Yang CH, Tsai PS, Wang TY, et al. Dexmedetomidine-ketamine combination mitigates acute lung injury in haemorrhagic shock rats [J]. Resuscitation, 2009, 80(10): 1204-10.
  • 6Correa-Meyer E, Pesce L, Guerrero C, et al. Cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells [J]. Am J Physiol Lung Cell Mol Physiol, 2002, 282(5): L883-91.
  • 7Di Paola R, Crisafulli C, Mazzon E, et al. Effect of PD98059, a selective MAPK3/MAPKI inhibitor, on acute lung injury in mice [J]. Int J lmmunopathol Pharmacol, 2009, 22(4): 937-50.
  • 8Li LF, Liao SK, Ko YS, et al. Hyperoxia increases ventilator- induced lung injury via mitogen-activated protein kinases: a prospective, controlled animal experiment [J]. Crit Care, 2007, 11 (1): R25.
  • 9Dasta JF, Kane-Gill SL, Pencina M, et al. A cost-minimization analysis of dexmedetomidine compared with midazolam for long-term sedation in the intensive care unit [J]. Crit Care Med, 2010, 38(2): 497-503.
  • 10Riker RR, Picard JT, Fraser GL, et al. Prospective evaluation of the Sedation-Agitation Scale for adult critically ill patients. Crit Care Med, 1999, 27: 1325-1329.

共引文献67

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引证文献12

二级引证文献90

中华全科医学
2016年 第8期

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