静息态fMRI研究遗忘型与小血管性轻度认知障碍功能连接密度变化

Resting-state f MRI study on changes of functional connectivity density in amnestic mild cognitive impairment and small vascular mild cognitive impairment

目的运用静息态功能磁共振研究遗忘型轻度认知障碍(a MCI)与小血管性轻度认知障碍(sv MCI)功能连接密度变化,加深其脑机制的认识。方法采集14例a MCI患者(a MCI组)、13例sv MCI患者(sv MCI组)与23例正常对照者(HC组)静息态功能磁共振数据,采用DPARSFA进行数据处理,获得功能连接密度FCD图,采用SPM8软件进行统计分析。结果 3组间FCD显著差异脑区包括右侧枕上回、右侧楔前叶、右侧顶上小叶、右侧海马旁回及左侧颞下回。与HC组比较,a MCI组右侧枕上回、右侧楔前叶、右侧顶上小叶FCD减低;sv MCI组右侧海马旁回FCD增加。而与a MCI组比较,sv MCI组左侧颞下回FCD相对增加。结论功能连接密度在3者间存在差异,sv MCI组与a MCI组FCD表现不同,提示两者间可能存在不同的神经病理机制。

Objective To observe the changes of functional connectivity density（FCD） in amnestic mild cognitive impairment（aMCI） and small vascular mild cognitive impairment（svMCI） using resting-state f MRI. Methods 14 a MCI patients,13 svMCI patients and 23 health controls（HC） participated in resting-state f MRI examinations.DPARSFA was used for data processing to get the FCD maps and SPM8 was used for statistic analysis. Results In the right superior occipital gyrus,right precuneus,right superior parietal lobe,right parahippocampal gyrus and left inferior temporal gyrus,the FCD values were significantly different among the 3 groups. Compared with HC,a MCI presented FCD decreased in the right superior occipital gyrus,right precuneus and right superior parietal lobe,while sv MCI showed increased FCD in the right parahippocampal gyrus. Compared with aMCI,svMCI showed FCD increase in the left inferior temporal gyrus. Conclusion There exist FCD differences among the 3 groups. svMCI shows different FCD compared with a MCI,which indiciates that there may be different neuropathology mechanisms between those two diseases.