神经节苷脂钠治疗新生儿自发性颅内出血的临床观察

Clinical observation on the treatment of spontaneous intracranial hemorrhage in newborn with ganglioside sodium

目的：探讨神经节苷脂钠治疗新生儿自发性颅内出血的临床效果。方法：选取2009年6月～2014年6月我院收治的64例临床资料齐全的新生儿自发性颅内出血患者,随机分为观察组与对照组。两组均接受常规对症治疗,观察组在此基础上,接受单唾液酸四己糖神经节苷脂钠治疗。14d后观察并记录两组临床疗效,并进行新生儿神经行为测定评分。结果：观察组NBNA评分正常率为90.63%,高于对照组的65.63%;观察组治疗总有效率为93.75%,高于对照组的68.75%,差异均有统计学意义（P〈0.05）。结论：新生儿颅内出血可导致神经功能发育不良,接受神经节苷脂钠治疗,能够有效改善患儿神经发育,提升患儿神经行为,值得临床推广。

Objective：To explore the effect of newborn with spontaneous intracranial hemorrhage treated by ganglioside sodium（gm1）.Methods：64 neonates of spontaneous intracranial hemorrhage from June.2009 to June.2014 in our hospital were enrolled in the study,and were divided into 2 groups randomly,each with 32 cases.Two groups of patients were treated with conventional symptomatic treatment,on the basis of this,observation group accepted gm1 treatment.observation and record the clinical efficacy of the two groups of newborn and the neonatal neurological test scores were compared.Results：The normal rate of NBNA score in the observation group was 90.63%,higher than that in the control group of 65.63%,the total efficiency of the observation group was 93.75%,also higher than68.75% in the control group,the differences were statistically significant（P〈0.05）.Conclusions：Neonatal intracranial hemorrhage can lead to poor neurological function,and accept the treatment of gm1,can effectively improve the nerve development of newborn,improve them with neurological behavior,it is worthy of clinical promotion.