摘要
糖尿病是受遗传和环境共同调控的一种代谢性疾病,发病率高且难以治愈。表观遗传DNA甲基化与糖尿病进程密切相关,是联通环境因素与基因因素的桥梁,DNA甲基化通过其对基因表达的调节作用影响疾病的发生与发展。肠道微生物菌群是糖尿病研究的新兴热点方向,能够提供甲基供体等有利于甲基化的便利条件。与肠道微生物菌群及其他相关代谢通路有关的DNA甲基化与糖尿病存在着密切的关系,其为解释糖尿病的致病机理及寻找有效干预糖尿病的手段提供了新的研究线索和思路。
Diabetes is a metabolic disease regulated by genetic and environment. It is difficult to cure and has a high incidence. The process of diabetes is closely related to epigenetic DNA methylation which regulates gene expression and is the bridge between environment and genetic factors. Intestinal flora can provide methyl donors, which contribute to methylation, and have become an emerging focus in diabetes research. DNA methylation relevant to intestinal flora and some metabolic pathways has close relationship with diabetes, and therefore provides a new clue for the pathogenesis and treatment of diabetes.
出处
《生命科学研究》
CAS
CSCD
2016年第3期271-277,共7页
Life Science Research
基金
国家自然科学基金项目(31100919
81371469)
浙江自然科学基金杰出青年项目(LR13H020003)
宁波大学王宽城基金
