合并低T3综合征急性心肌梗死患者临床特征分析研究

Clinical characteristics of acute myocardium infarction patients complicated with low triiodothyronine syndrome

目的 分析急性心肌梗死合并低T3综合征患者的临床特征.方法 序贯收集265例急性心肌梗死患者甲状腺功能检查及冠脉造影资等临床资料,按入院时血清游离三碘甲状腺原氨酸（FT3）水平分为低T3组与正常T3组,并分析两组患者临床特征的差异.结果 与正常T3组相比,低T3组发病年龄高[（68.46±10.62）岁vs.（60.79±11.24）岁,P＜0.01],血红蛋白浓度减低[（125.76±17.66） g/L vs.（135.94±16.37） g/L,P＜0.01],总胆固醇浓度低[（4.81±1.35） mmol/Lvs.（5.20±1.22）mmol/L,P＜ 0.01]、左心室射血分数低[（58.17±7.95）％vs.（62.71±6.92）％,P＜0.01],严重心血管事件发生频率高（6.5％vs.1.4％,P＜0.05）,三支血管病变患者比例高（55.3％ vs.16.9％,P＜0.01）,Killip Ⅲ＋Ⅳ级患者比例高（30.9％ vs.3.5％,P＜0.01）.结论 急性心肌梗死合并低T3综合征患者具有病情严重,预后差的特征.

Objective To investigate the clinical characteristics of acute myocardium infarction （AMI）patients complicated with low triiodothyronine （T3） syndrome.Methods The clinical data,such as thyroid function detection and coronary angiography,of 265 AMI patients were collected.According to the serum level of free triiodothyronine （FT3）,the patients were divided into a low T3 group and a normal T3 group.The clinical characteristics of these two group were analyzed.Results The onset age [（68.46±10.62） vs.（60.79±11.24）],the frequency of cardiovascular events （6.5% vs.1.4%）,and the proportions of triple affected vessel （55.3% vs.16.9%） and Killip Ⅲ ＋ Ⅳ （30.9% vs.3.5%） were higher and the concentrations of hemoglobin [（125.76±17.66）g/L vs.（135.94±16.37） g/L] and total cholesterol [（4.81±1.35） mmol/L vs.（5.20±1.22） mmol/L] and the left ventricular ejection fraction [（58.17±7.95） % vs.（62.71±6.92）%] were lower in the low T3 group than in the normal T3 group（P〈0.01）.Conclusions AMI patients complicated with low T3 syndrome have more severe condition and worse prognosis.