内镜联合血清胃蛋白酶原检测对老年萎缩性胃炎的诊断分析

Detection of serum pepsinogen combined with endoscope in diagnosis of senile atrophic gastritis

目的 研究内镜联合血清胃蛋白酶原检测对于老年萎缩性胃炎的诊断价值,为诊断提供参考.方法 选择本院2014年5月至2015年8月收治的88例老年萎缩性胃炎患者作为观察对象,另外选择本院体检检测结果显示健康者88例为对照组.对所有入选对象实施内镜联合血清胃蛋白酶原检测,对比体内的血清胃蛋白酶原水平.结果 对照组体内的PGⅡ水平明显低于观察组;观察组PGⅠ与PG Ⅰ/PGⅡ均明显低于对照组（P＜0.05）.经Logistic回归分析,PG Ⅰ与PG Ⅰ/PGⅡ检测均P＜0.05;PGⅠ与PG Ⅰ/PGⅡ水平减小对于患者的诊断价值较高,方程分辨能力分别为83.3％、80.4％,经方程x2检验,结果差异具有统计学意义;中度以及重度患者PGⅠ以及PG Ⅰ/PGⅡ均明显低于轻度患者,重度患者PG Ⅰ与PG Ⅰ/PGⅡ水平明显低于中度患者.结论 使用内镜联合血清胃蛋白酶原检测对于老年萎缩性胃炎具有十分重要的价值,推荐使用.

Objective To study the value of the detection of serum pepsinogen and endoscope in the diagnosis of senile atrophic gastritis.Methods 88 elderly patients with atrophic gastritis treated at our hospital from May,2014 to August,2015 were selected as study objects.And 88 subjects confirmed healthy by physical examination at our hospital were selected as a control group.The serum level pepsinogen was detected in all the objects.All the objects were checked with endoscope.And the results were compared between these two groups.Results The level of PG Ⅱ was significantly lower and the level of PG Ⅰ and PG Ⅰ/PG Ⅱ were significantly higher in the control group than in the observation group,with statistical differences （P〉0.05）.Logistic regression analysis showed statistical significance;PG Ⅰ level and PG Ⅰ/PG Ⅱ detection P 〈 0.05.The decrease of PG Ⅰ and PG Ⅰ/PG Ⅱ had higher diagnostic value for the patients;the ability to distinguish equation were 83.3% and 80.4%;the equation of x 2 test showed that the results were statistically significant （P 〈 0.05）.Moderate and severe patients had significantly lower PG Ⅰ and PG Ⅰ and/PG Ⅱ levels than mild patients and severe than moderate.Conclusions Endoscope combined with serum pepsinogen detection in the diagnosis of senile atrophic gastritis has very important value.It is worth being recommended.