摘要
目的探讨尿液中胱抑素C(Cys-C)和α1-微球蛋白(α1-MG)在糖尿病肾病肾损伤诊断中的意义。方法选取糖尿病肾病患者共168例,正常对照组40例。采用定量ELISA方法测定对照组和DN组Cys-C和α1-MG的含量,并对测定结果进行统计分析。结果 DN组尿Cys-C和α1-MG含量均显著高于对照组,差异具有统计学意义(P<0.05)。DN组尿Cys-C和α1-MG的单项检测阳性率分别为62.5%和35.1%;两项指标联合检测的阳性率为79.8%。结论上述指标的联合检测大大提高了DN患者诊断的准确性。
Objective To explore the significance of urinary cystatin C（ Cys- C） and α1- microglobulin（ α1- MG） in the diagnosis of the progression of diabetic nephropathy（ DN）. Methods 168 cases with DN and 40 cases were selected respectively as the DN group and the control group,and the contents of Cys- C and α1- MG between the two groups were determined by ELISA assay. The detection results were conducted for statistical analysis. Results The contents of Cys- C and α1- MG in DN group were significantly higher than that in the control group,and the difference statistically significant（ P〈0. 05）. In DN patients,the positive rates of Cys- C and α1- MG were 62. 5% and 35. 1%,respectively. And the total positive rate of the combined detection was 79. 8% in DN patients. Conclusion The combined detection of the above premeters greatly improved the diagnostic accuracy of DN patients.
出处
《中国卫生检验杂志》
CAS
2016年第12期1729-1730,1733,共3页
Chinese Journal of Health Laboratory Technology
基金
兰州市科学计划项目(2014-rc-61)
