OSCC患者瘦素水平测定及其临床意义的研究

The levels of salivary and serum leptin in patients with oral squamous cell carcinoma and their potential clinical significance

目的:评价口腔鳞状细胞癌(OSCC)病人唾液和血液中的瘦素的水平变化及其临床意义。方法:对40例非口腔鳞状细胞癌患者(非OSCC组)和50例口腔鳞状细胞癌患者(OSCC组),唾液和血液中的瘦素水平通过酶联免疫吸附实验测定。结果:OSCC组唾液和血液中瘦素水平明显下降,与非OSCC组比较差异具有统计学意义(P<0.01),且唾液和血液中瘦素水平和病人的体重分布,病理分级,TNM分期具有显著的相关性。同时,唾液和血液中的瘦素水平在OSCC组和非OSCC组之间有较高的相关性。结论:唾液和血液中瘦素的水平可能参与OSCC的病理进程,可能是检测OSCC病理进程,提示预后的有效标志物。

Objective：The purposes of the present study are to assess the expression levels of leptin in serum and salivary in patients with squamous cell carcinoma（OSCC）. Method：Enrolled participants in this study included 50 patients with OSCC and 40 healthy volunteers. Serum and salivary leptin levels were measured via enzyme-linked immunosorbent assay（ELISA） method. Result：A significant down-regulation of leptin in salivary and serum in OSCC was found when compared with control subjects. Moreover, a significant correlation was shown between serum and salivary leptin levels, body mass index and various histopathological and TNM（tumour nodes metastasis） staging variants of OSCC. In addition, a highly significant correlation was shown between salivary and serum leptin levels in both groups.Conclusion：The results of this study demonstrate a potential mechanism of salivary and serum leptin levels in OSCC. Serum and salivary leptin may play a key role in OSCC.