乌尔曼缩合法合成N-苯基邻氨基苯甲酸的研究

Study on Synthesize of N- Phenylanthranilic Acid via Ullmann Condensation Method

以邻卤苯甲酸和苯胺为主要原料,采用乌尔曼缩合法合成了N-苯基邻氨基苯甲酸,研究了原料、催化剂、温度、溶剂等因素对反应的影响。实验结果表明,邻碘苯甲酸的反应活性较高;氧化铁铜催化剂的活性对温度变化不敏感,在不同温度下均有较好的催化效果,而以铜粉、氧化铜或氯化铜为催化剂时反应温度越高催化效果越好;以二甲基亚砜(DMSO)为溶剂时产物收率整体较高,最高可达92%。

N- phenylanthranilic acid was synthesized with o- halo- benzoic acid and aniline as the main materials via Ullmann condensation method,and the effects of the materials,catalyst,temperature,and solvent,etc. on the reaction were studied. The experimental results have shown that the reactive activity of o- iodobenzoic acid is higher,the activity of iron oxide or copper oxide catalyst is insensitive to temperature change and iron oxide or copper oxide catalyst has good catalytic effect at different temperatures,the higher the reaction temperature is the better the catalytic effect is when copper powder,copper oxide or copper chloride is used as the catalyst,and the overall yield of product is high and can reach 92% when dimethyl sulfoxide（ DMSO） is used as the solvent.