人参皂苷与环糊精包合物的研究进展

Progress of ginsenosides and cyclodextrin inclusion complexes

人参皂苷是从人参、西洋参和三七中提取的主要活性成分,其药效价值相当高,但因其在水中几乎不溶,生物利用度极低,因此极大的限制了其在临床上的应用.环糊精具有独特的性质,其"腔内疏水、腔外亲水",可以选择性的包合人参皂苷等客体分子.环糊精与人参皂苷形成包合物后可以改变客体分子的某些物理化学性能,如水溶性、稳定性以及光学性质等,以此来提高其生物利用度.

Ginsenoside is the main active ingredient extracted from ginseng,American ginseng and pseudo-ginseng,and its medicinal value is very high.For its almost insoluble in water and extremely low bioavailability,it greatly limits the application value in clinic.Owing to hydrophobic cavity and external cavity hydrophilic,cyclodextrin can be selectively inclusion ginsenoside and some guest molecules.The formation of inclusion complex can change some of the physical and chemical properties of guest molecules,such as solubility,stability,and optical properties,which can improve its bioavailability.