2型糖尿病肾病患者检测血清基质金属蛋白酶-10的意义

Study on the Significance of Detecting MMP-10 Level in Patients with Type 2 Diabetic Nephropathy

目的探讨血清基质金属蛋白酶-10（MMP-10）水平与2型糖尿病肾病发病的关系。方法将100例2型糖尿病肾病患者按糖尿病肾病（DN）诊断标准分为糖尿病无肾病（DM）组（42例）与DN组（58例）。按照 Mogenson分期将DN组分为DN早期（DN1）30例，DN晚期（DN2）28例。另择60例健康体检者作为正常对照（NC）组。同时检测糖化血红蛋白（HbA1c）、肌酐（Scr）、尿素氮（BUN）、24 h尿微量清蛋白排泄率（UAER）、β2微球蛋白（β2-MG）和 MMP-10，进行相关的统计学分析。结果 DM，DN和 NC组 HbA1c，Scr，UAER，BUN，β2-MG和 MMP-10指标差异有统计学意义（F＝6.478～10.892，均P＜0.05）。DM组和 NC 组间除 HbA1c 外其它检测指标差异均无统计学意义（t＝1.421～2.637，均 P＞0.05），而DN组与NC组比较差异均有统计学意义（t＝8.451～26.678，均P＜0.05）。DN组和DM组间除 HbA1c外其它检测指标差异均有统计学意义（t＝6.371～21.673，均P＜0.05）。DN1组和DN2组间 HbA1c，Scr，UAER，BUN和β2-MG差异无统计学意义（t＝0.891～1.385，均P＞0.05）。而DN2组MMP-10水平明显比DN1组高，两组差异有统计学意义（t＝86.371，P＜0.01）。结论血清 MMP-10水平可能是2型糖尿病肾病患者肾脏损伤程度的靶标。

Objective To explore the significance of detecting serum MMP-10 in type 2 diabetic nephropathy.Methods 100 diabetic patients with suspected DN were devided into two groups,that was DM（42 cases）and DN（58 cases）group,and 60 casescontrolgroup（NC）.By Mogenson,DN1（30 cases）and DN2（28 cases）,HbA1c,BUN,Scr,UAER,β2-MG and MMP-10 leves were detected by the standard method.Results There were obvious differences of HbA1c,BUN,Scr,UAER,β2-MG and MMP-10 levels among DN,DM and NC（P〈0.05）.Apart of HbA1c,others were no differences between DM group and NC group（P〉0.05）.DN group was higher significantly than these in DM group（P〈0.05）,and HbA1c,BUN,Scr,UAER, andβ2-MG levels had no statistical difference between DN1 and DN2 group.MMP-10 level in DN2 was higher than that in DN1 group（P〈0.05）.Conclusion MMP-10 in serum may be a role indicator for impairment of renal function for diagnosis of type 2 diabetic nephropathy.