茚及其衍生物的催化不对称合成

Catalytic Asymmetric Syntheses of Indenes and Their Derivatives

茚及其衍生物广泛存在于自然界中,其中多官能团化的茚类化合物大多具有重要的生物活性,因而非常具有成为药物的先导化合物的潜力。特别是茚类化合物的不对称合成吸引了有机化学家们的广泛关注,最近有许多相应的合成方法研究被报道,包括外消旋体拆分、手性辅基及底物诱导的合成和手性催化合成等。本文总结了茚及其衍生物的催化不对称合成研究进展,重点介绍过渡金属及有机小分子不对称催化反应,并对该领域的研究前景进行了展望。

Indenes and their derivatives widely exists in natural world,and some of them bearing multifunctional groups are very potential to become the lead compounds in drug because of their important bioactivities.In particular,asymmetric syntheses of indenes have attracted the extensive attention of organic chemists.Recently,many synthetic methods of them have been reported,including resolution of racemic mixture,syntheses of chiral auxiliary or substrate＇ s induction,as well as chiral catalytic synthesis.In this review,we summarize the asymmetric syntheses of these compounds,and focus on the transition metal-catalyzed and organocatalytic asymmetric reaction.Finally,the further research on this field is also discussed.