孟鲁司特钠联合阿奇霉素治疗小儿喘息性支气管炎的临床疗效

The Clinical Efficacy of Montelukast Combined with Azithromycin in Treatment of Children with Asthmatic Bronchitis

目的:观察孟鲁司特钠联合阿奇霉素治疗小儿喘息性支气管炎的临床疗效。方法:选取2014年1月至2015年12月遵义市妇幼保健院收治的小儿喘息性支气管炎患儿为研究对象,随机分为对照组和试验组各112例。对照组采用阿奇霉素治疗,试验组采用孟鲁司特钠联合阿奇霉素治疗,比较两组患儿的临床疗效、临床症状消失时间以及C反应蛋白(CRP)水平。结果:治疗后,实验组患儿体温恢复正常时间、喘息消失时间、咳嗽消失时间、哮鸣音消失时间及住院时间均明显短于对照组,差异均有统计学意义(P<0.05);试验组与对照组CRP水平均明显降低,与治疗前比较差异均有统计学意义(P<0.05),且试验组降低幅度明显大于对照组(P<0.05);试验组患儿的总有效率为94.64%,对照组患儿的总有效率为78.57%,两组比较差异有统计学意义(P<0.05)。治疗过程中,试验组患儿不良反应发生率为4.46%,对照组患儿不良反应发生率为12.50%,两组比较差异有统计学意义(P<0.05);出院后,试验组患儿复发率为5.36%,对照组患儿复发率为16.07%,两组比较差异有统计学意义(P<0.05)。结论:小儿喘息性支气管炎采用孟鲁司特钠联合阿奇霉素治疗的临床效果显著,不良反应少,值得临床推广应用。

Objective： To investigate the clinical efficacy of montelukast combined with azithromycin in treatment of children with asthmatic bronchitis. Methods： From January 2014 to December 2015,224 asthmatic bronchitis children admitted into Zunyi Maternity and Child Care Hospital were randomly divided into two groups： 112 cases in the control group and 112 cases in the experimental group.The control group accepted azithromycin and experimental group accepted montelukast combined with azithromycin. The clinical efficacy,disappear time of clinical symptoms and the level of CRP in two groups were recorded and compared. Results： After treatment,the time of temperature returned to normal,disappear time of wheezing,cough and hospital stay had shorten in the experimental group,compared with the control group（ P 0. 05）. The level of CRP had decreased in the experimental group,compared with the control group（ P〈0. 05）. In the experimental group,the total effective rate was 94. 64%,which had significantly increased,compared with the control group（ 78. 57%,P〈0. 05）. The rates of adverse reactions and recurrence in the experimental group were lower than the control group（ P 0. 05）. Conclusion： The clinical effect of montelukast combined with azithromycin in treatment of asthmatic bronchitis children using is significant,with the lower incidence of adverse reactions.