摘要
【目的】探讨趋化因子受体CXCR7在原发性肝细胞肝癌(PHC)中的表达情况及其临床意义。【方法】应用组织芯片和免疫组化法检测35对肝癌、癌旁组织和6例正常肝组织中CXCR7的表达,并分析其表达与肝癌临床病理特征及预后的相关性。【结果】cxcR7在35例PHC患者组织中的阳性表达率为88.6%(31/35),显著高于配对癌旁肝组织37.14%(13/35)以及正常肝组织0(0/6);CXCR7的高表达与PHC组织学分型、临床分期、淋巴结转移和血清AFP含量呈正相关(P〈0.05),与其他,临床指标无相关性(P〉0.05);CXCR7阳性表达患者的中位生存时间相对于阴性表达患者均较短,且差异具有统计学意义(P=0.001)。【结论】CXCR7在PHC患者中的阳性表达情况与临床预后密切相关,并且可分别作为独立的预测PHC患者预后的指标。
[Objective] To investigate the expression of chemokine receptor CXCR7 and its clinical significance in primary hepatocellular carcinoma (PHC). [Methods]Tissue microarray and immunohistochemistry (IHC) were used to detect the expression of CXCR7 in 35 paired PHC,the adjacent liver tissues and 6 cases of normal liver tissues, and its expression related with clinical pathological characteristics and prognosis of hepatocellular carcinoma were analyzed.[Results]The positive expression rate of CXCR7 in the tissues of 35 patients with PHC was 88.6% (31/35), which was significantly higher than that in matched adjacent liver tissues 37.14% (13/35) and 0 (0/6) in the normal liver tissues; The high expression of CXCR7 was positively correlated with the histological type, clinical stage, lymph node metastasis and serum AFP content of PHC ( P〈0.05), and there was no correlation with other clinical parameters ( P 〈0.05); The median survival time of CXCR7 positive patients was shorter than that of the negative expression, and the difference was statistically significant ( P 〈0.001). [Conclusion] The positive expression of CXCR7 in PHC patients is closely related with clinical prognosis, and can be used as independent predictors of prognosis of PHC patients.
出处
《医学临床研究》
CAS
2016年第6期1117-1119,1122,共4页
Journal of Clinical Research
关键词
受体
CXCR
癌
肝细胞/病理学
肿瘤分期
淋巴转移
预后
Receptors, CXCR
Carcinoma, Hepatocellular/PA
Neoplasm Staging
Lymphatic Metastasis
Prognosis