趋化因子受体CXCR7在原发性肝细胞肝癌中的表达及意义

Expression of Chemokine Receptor CXCR7 and its Role in Primary Hepatocellular Carcinoma

【目的】探讨趋化因子受体CXCR7在原发性肝细胞肝癌（PHC）中的表达情况及其临床意义。【方法】应用组织芯片和免疫组化法检测35对肝癌、癌旁组织和6例正常肝组织中CXCR7的表达，并分析其表达与肝癌临床病理特征及预后的相关性。【结果】cxcR7在35例PHC患者组织中的阳性表达率为88．6％（31／35），显著高于配对癌旁肝组织37．14％（13／35）以及正常肝组织0（0／6）；CXCR7的高表达与PHC组织学分型、临床分期、淋巴结转移和血清AFP含量呈正相关（P〈0．05），与其他，临床指标无相关性（P〉0．05）；CXCR7阳性表达患者的中位生存时间相对于阴性表达患者均较短，且差异具有统计学意义（P=0．001）。【结论】CXCR7在PHC患者中的阳性表达情况与临床预后密切相关，并且可分别作为独立的预测PHC患者预后的指标。

[Objective] To investigate the expression of chemokine receptor CXCR7 and its clinical significance in primary hepatocellular carcinoma （PHC）. [Methods]Tissue microarray and immunohistochemistry （IHC） were used to detect the expression of CXCR7 in 35 paired PHC,the adjacent liver tissues and 6 cases of normal liver tissues, and its expression related with clinical pathological characteristics and prognosis of hepatocellular carcinoma were analyzed.[Results]The positive expression rate of CXCR7 in the tissues of 35 patients with PHC was 88.6% （31/35）, which was significantly higher than that in matched adjacent liver tissues 37.14% （13/35） and 0 （0/6） in the normal liver tissues; The high expression of CXCR7 was positively correlated with the histological type, clinical stage, lymph node metastasis and serum AFP content of PHC （ P〈0.05）, and there was no correlation with other clinical parameters （ P 〈0.05）; The median survival time of CXCR7 positive patients was shorter than that of the negative expression, and the difference was statistically significant （ P 〈0.001）. [Conclusion] The positive expression of CXCR7 in PHC patients is closely related with clinical prognosis, and can be used as independent predictors of prognosis of PHC patients.