转化生长因子-β对结核性胸膜纤维化作用的研究进展

The research progress of transforming growth factor-β in the action of tuberculous pleural fibrosis

胸膜纤维化是结核性胸膜炎疾病进展中一个重要的病理改变。目前大多数研究集中于抗结核药物治疗和胸膜纤维板剥脱手术,对于结核性胸膜纤维化机制的研究相对较少。但实际上,胸膜纤维化对该疾病的预后更具有指导意义。已有研究发现,转化生长因子-β(transforming growth factor-β,TGF-β)与结核性胸膜纤维化的关系密切,本文就TGF-β在结核性胸膜纤维化中的作用予以综述,以进一步提高对结核性胸膜纤维化的理论认识。

Pleural fibrosis is an important pathological change in tuberculous pleurisy progression.At present, most researches focus on the treatment of anti-tuberculosis drugs and pleural fiber-board stripped surgery, howerer the study of the mechanism of tuberculous pleural fibrosis is relatively little. In fact, pleural fibrosis has a more guiding significance for the prognosis of the disease. Studies have found that transforming growth factor beta （TGF-β） had been closely related with the tuberculous pleural fibrosis. This article reviews the role of TGF-β in the tuberculous pleural fibrosis, so as to further improve the theoretical understanding of tuberculous pleural fibrosis.