氢气选择性抗氧化作用在内耳急性损伤防治中的作用

Selective Antioxidant Effect and Protective Role of Hydrogen against Acute Inner Ear Injury

氧化应激产生的活性氧(Reactive Oxygen Species,ROS)过量参与了包括噪声性听力损伤、药物性聋在内的内耳急性损伤过程。近年来研究表明,氢气是一种安全有效的抗氧化剂,可以迅速到达患处与氧化性较强活性氧进行反应,并有效对抗氧化应激。氢气的选择性抗氧化作用可能与降低氧化应激,减轻细胞凋亡,以及调节细胞信号通路相关。研究氢气的抗氧化作用为治疗内耳急性损伤性疾病提供了新思路。本文就氢气在选择性抗氧化作用及其可能的作用机制,以及氢气在内耳急性损伤防治中的研究进展等方面进行综述。

Excessive Reactive Oxygen Species （ROS） in noise-induced or drug-induced hearing loss causes inner earserious damage. Recent studies have shown that hydrogen, which acts as a safe and effective antioxidant by reaching the re-active area quickly and reacting with strong oxidizing ROS, can alleviate oxidative stress effectively. Selective antioxidant effect by hydrogen may be related to reducing oxidative stress, decreasing cell apoptosis and regulating cell signaling path- ways. Studying antioxidant effects by hydrogen provides a new approach to the treatment of inner ear acute injury. The pres- ent review summarizes possible mechanisms of hydrogen in preventing inner ear from acute injury.