冻干重组人脑利钠肽低剂量持续泵入72h对慢性心力衰竭患者血浆中NT-proBNP及LVEF指数的影响

Effect of continuous infusion of low-dose rhBNP for 72h on plasma NT-pro BNP and LVEF index of patients with chronic heart failure

目的分析冻干重组人脑利钠肽(新活素)低剂量持续泵入72 h后,慢性心力衰竭患者血浆中N末端B型利钠肽前体(NT-pro BNP)以及左室射血分数(LVEF)的指数变化,评价其影响。方法选择我院心内科2013年6月至2015年6月收治的120例慢性心力衰竭患者,将其分为观察组和对照组,每组60例。观察组在常规治疗的基础上加用冻干重组人脑利钠肽0.01μg/(kg·min),持续泵入72 h;对照组在常规治疗的基础上加用米力农注射液0.5μg/(kg·min),持续泵入72 h。治疗前后分别检测血浆中NT-pro BNP和LVEF。结果治疗后两组慢性心力衰竭患者血浆中NT-pro BNP和LVEF均有明显改善,治疗后观察组中NT-pro BNP明显低于对照组,LVEF指数明显高于对照组,总有效率明显高于对照组,差异均有统计学意义(P<0.05)。结论冻干重组人脑利钠肽低剂量持续泵入72 h,可明显改善慢性心力衰竭患者血浆中的NT-pro BNP和LVEF指标,提高该疾病治疗的总有效率。

Objective To evaluate the effect of continuous infusion of low-dose rhBNP for 72 h on plasma NT-proBNP and LVEF index of patients with chronic heart failure.Methods Totally 120 cases of chronic heart failure in our hospital from June 2013 to June 2015 were collected and divided into observation group and control group,60 cases in each group.Patients in observation group were given rhBNP 0.01 μg/（kg·min） by continuous infusion for72 h on the basis of conventional therapy.Control group was given milrinone injection 0.5 μg/（kg·min） continuous infusion for 72 h and conventional therapy.Plasma N-terminal B precursor type natriuretic peptide（NT-proBNP） and left ventricular ejection fraction（LVEF） index were measured before and after treatment.Results After treatment,the plasma N-terminal B-type natriuretic peptide precursor（NT-proBNP） and left ventricular ejection fraction（LVEF） in the two groups were significantly improved（P〈0.05）;the NT-proBNP level in observation group was lower than that of control group（P〈0.05）,while the LVEF index was higher（P〈 0.05）;the total effective rate in observation group was significantly higher than that of control group,there being significant difference（P〈 0.05）.Conclusion Continuous infusion of low-dose rhBNP for 72 h can significantly improve plasma NT-proBNP level and LVEF indicators of the patients with chronic heart failure,and increase the total efficiency.