泛素-蛋白酶体抑制剂对血管平滑肌细胞凋亡和动脉粥样硬化的影响

Effects of ubiquitin-proteasome inhibitor on apoptosis of vascular smooth muscle cells and atherosclerosis

泛素-蛋白酶体系统(Ubiquitin proteasome system,UPS)是真核细胞内蛋白质降解的核心途径,对细胞周期、炎症反应、细胞凋亡的调节起十分重要的作用。血管平滑肌细胞(Vascular smooth muscle cells,VSM C)作为血管壁的重要细胞成分,其增殖与凋亡的失平衡是决定动脉粥样硬化发生、发展的关键环节。在VSM C中,细胞凋亡与UPS活性密切相关,且UPS对动脉粥样硬化各个阶段有显著的调节作用。泛素-蛋白酶体抑制剂(Ubiquitin-proteasome inhibitors,UPI)通过抑制凋亡相关蛋白的降解,从而调控VSMC的凋亡,影响动脉粥样硬化形成的各个阶段。本文综述了UPI对VSMC凋亡的影响及其在动脉粥样硬化各阶段的调节作用。

Ubiquitin-proteasome system（UPS） is the principal degradation route of proteins in eukaryotic cells,thus playing a crucial role in the regulation of cell cycle inflammation and apoptosis.The imbalance between proliferation and apoptosis of vascular smooth muscle cells（VSMC）,an important cellular component of the vessel wall,is a key in occurrence and development of atherosclerosis.VSMC apoptosis has been associated with UPS,and the UPS has a significant regulatory role in the various stages of atherosclerosis.Proteasome inhibitor（UPI） affects all stages of atherosclerosis formation by inhibiting the degradation of apoptosis-related proteins and regulating the apoptosis of VSMC.This paper reviews the effect of UPI on VSMC apoptosis and regulation of the various stages of atherosclerosis.