麻醉对肿瘤患者免疫功能及术后复发的影响

Effects of anesthesia on the immune function and recurrence after surgery in patients with tumor

目前,癌症仍是世界上导致高发病率及死亡率的主要原因。即使清除原发病灶,复发和转移仍是导致死亡的主要原因。肿瘤患者免疫功能低下,麻醉、手术及疼痛等刺激会使患者的免疫功能进一步受损,对疾病的恢复非常不利,故围术期免疫功能的保护对肿瘤患者非常重要。麻醉可减少手术引起的应激反应,而麻醉本身在一定程度上影响患者的免疫功能,尤其以对T细胞及NK细胞的影响为主。因此,肿瘤患者的麻醉管理可能潜在地影响其长期预后。本文就不同麻醉方法及不同麻醉药物对肿瘤患者免疫功能及术后复发转移的影响进行综述。

At present,cancer is still the key cause leading to high morbidity and mortality in the world.Even if the primary lesion has been cleared,its recurrence and metastasis is still the leading cause of death.The immune function of patients with tumor is low,and anesthesia,surgery and pain stimulation will cause further damage to the patient＇s immune function,which is a disadvantage in the recovery of the patients,so the perioperative protection of immune function of tumor patients will be very important.Anesthesia can reduce the stress reaction caused by surgery,and anesthesia itself affects the patient＇s immune function to a certain extent,especially T cells and NK cells.Therefore,the management of anesthesia could potentially influence the long-term outcome of the patients with tumor.The retrospective review summarizes the effect of different anesthetic techniques and anesthetics on the immune function and the postoperative recurrence and metastasis of patients with tumor.