循经论治急性痛风性关节炎临床对照研究

Clinical control study on the effects of channel ushering drug in treating acute gouty arthritis based on the syndrome differentiation of channel theory

目的:观察循经论治急性痛风性关节炎的临床疗效。方法:将急性痛风性关节炎患者70例随机分组,两组患者均采用相同的西医常规治疗,治疗组:通过中医辨证类型予以对应的组方的前提下,按循经论治的理论配伍相应的引经药;对照组:仅通过中医辨证类型予以对应的组方口服汤药治疗,治疗周期为1周。两组患者治疗前后各项指标进行评估。结果;两组患者治疗前后白细胞数、中性粒细胞百分比、C反应蛋白CRP水平,血沉(ESR)均有显著下降(P<0.05),其中治疗组较对照组明显(P<0.05)。血尿酸水平UA及β2微球蛋白在治疗组中治疗前后比较差异有统计学意义(P<0.05),两组患者治疗前后疼痛评分,关节肿胀评分,关节活动情况评分均有显著改善(P<0.05)。结论:循经论治急性痛风性关节炎具有提高临床疗效的作用。

Objective： To investigate the clinical effect of channel ushering drug in treatment of acute gouty arthritis based on the syndrome differentiation of channel theory. Methods： Seventy cases of patients with acute gouty arthritis were randomly divided into 2 groups. Two groups of patients were treated with the same regular western medical therapy. The channel ushering drugs based on the syndrome differentiation of channel theory were used in the experimental group. The control group was treated only with syndrome differentiation and treatment. The course of treatment was one week. The therapeutic effect was observed. Results： After treatment, the Leukocyte count, neutrophils percentage, c-reactive protein（CRP）, erythrocyte sedimentation rate（ESR） were significantly decreased in both groups（P〈0.05）. Serum uric acid（UA） and microglobulin beta 2 were significant difference between before and after treatment in the experimental group（P〈0.05）. Local pain, swelling of joint, joint activity were significant difference in both groups between before and after treatment（P〈0.05）. There was a significant difference between two groups after treatment in syndrome of accumulated dampness-heat（P〈0.05）. Conclusion： Channel ushering drug based on the syndrome differentiation of channel theory was effective for the treatment of acute gouty arthritis.