摘要
目的:研究蒙药忠伦阿汤干预活动期类风湿关节炎(RA)蒙医证候疗效及实验室指标的影响。方法:将90例活动期RA患者随机分为治疗组和对照组,每组45例。对照组应用甲氨蝶呤片10mg/次,1次/周,饭后服;治疗组在对照组基础上加用蒙药忠伦阿汤,每日2次,每次5g,水煎服,两组疗程均为12周。观察患者治疗前后蒙医证候症状体征及RF、CRP、ESR、抗CCP抗体的变化情况。结果:治疗后两组患者关节发热、发红、肿胀、灼痛或刺痛、遇热加剧,发热、寒战、全身不适、乏力、食欲减退等蒙医证候症状、体征均较本组治疗前明显改善(P<0.01);治疗组治疗后蒙医证候症状、体征的改善效果明显优于对照组同期(P<0.01)。治疗后两组患者RF、CRP、ESR均比本组治疗前明显改善(P<0.01),治疗组治疗后RF、CRP、ESR的改善明显优于对照组(P<0.01);治疗组治疗后抗CCP抗体较治疗前明显改善(P<0.01)。结论:蒙药忠伦阿汤能够改善活动期RA蒙医证候症状、体征及RF、CRP、ESR等实验室指标,可与抗风湿药(甲氨蝶呤)联合使用,有较好的协同作用。
Objective: To study the syndrome curative effect and laboratory indexes of Mongolian medicine Zhonglun A Decoction in treating active stage of rheumatoid arthritis(RA). Methods: Ninety patients with active stage of RA were randomly divided into treatment group and control group, 45 cases in each group. The patients in control group were given Methotrexate Tablets 10mg/times, 1 time/week, after meals; the patients in treatment group were combined with Mongolian medicine Zhonglun A Decoction, two times daily, every time 5g, and decocted in water for oral dose. All the patients were treated for 12 weeks. Before and after treatment, the symptoms and signs of traditional Mongolian medicine syndrome and RF, CRP, ESR, anti CCP antibody and other laboratory indexes in patients were observed. Results: After treatment, the Mongolian medicine syndrome symptoms and signs of all the indexes of patients in the two groups were significantly improved(P〈0.01); after treatment, the improving effect of symptoms and signs of Mongolian medicine syndrome in treatment group was better than control group, with significant difference(P〈0.01). After treatment, the RF, CRP, ESR and other laboratory indexes of patients in both two groups were obviously improved(P〈0.01); after treatment, the improving effect of RF, CRP, ESR and other laboratory indexes in the treatment group was better than control group(P〈0.01); after treatment, the anti CCP antibody in treatment group was significantly improved(P〈0.01). Conclusion: Mongolian medicine Zhonglun A Decoction can improve the Mongolian medicine syndrome symptoms, signs and RF, CRP, ESR and other laboratory indexes of active stage of RA, and has good synergistic effect when combined with antirheumatic drugs(methotrexate).
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2016年第7期2860-2863,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
内蒙古科技厅应用研究项目(No.201100114)~~
关键词
蒙药
忠伦阿汤
活动期类RA
蒙医证候
症状
体征
实验室指标
Mongolian medicine
Zhonglun A Decoction
Active stage of rheumatoid arthritis
Mongolian medicine syndromes
Symptoms
Signs
Laboratory indexes