C反应蛋白联合血浆纤维蛋白原检测对慢性阻塞性肺疾病急性加重期的诊断价值

Value of C-reactive Protein Combined with Plasma Fibrinogen Detection in Diagnosis of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的探讨C-反应蛋白和血浆纤维蛋白原的检测在慢性阻塞性肺病急性加重期诊断价值。方法采用病例对照研究,随机选择2015年1—8月在该院住院治疗的慢性阻塞性肺疾病患者98例,其中急性加重期56例(试验组)和稳定期42例(对照组),检测其血清C-反应蛋白和血浆纤维蛋白原水平。结果试验组C-反应蛋白(61.4±10.46)mg/L、血浆纤维蛋白原(5.9±1.15)g/L,对照组C-反应蛋白(8.2±3.62)mg/L,血浆纤维蛋白原(3.8±0.4 1)g/L,慢性阻塞性肺疾病急性加重期C-反应蛋白和血浆纤维蛋白原水平显著高于稳定期(P<0.01)。结论 C-反应蛋白和纤维蛋白原可作为慢性阻塞性肺病急性加重期患者感染早期诊断和病情监测的指标之一。C-反应蛋白检测值为(8.2±3.62)

Objective To discuss the value of c-reactive protein combined with plasma fibrinogen detection in diagnosis of acute exacerbation of chronic obstructive pulmonary disease. Methods 98 cases of inpatients with chronic obstructive pulmonary disease treated in our hospital from January 2015 to August 2015 were randomly selected and divided into the test group with 56 cases （acute exacerbation phase） and the control group with 42 cases （slationary phase）, the serum c- reactive proteins and plasma fibrinogen levels were detected. Results The c-reactive protein and plasma fibrinogen levels were respectively （61.4±10.46） mg/L and （5.9±1.15） g/L in the test group and （8.2±3.62） mg/L and （3.8±0.4 1） g/L in the control group, the c-reactive protein and plasma fibrinogen levels of chronic obstructive pulmonary disease in the acute exacerbation phase were obviously higher than those in the slationary phase （P〈O.O1）. Conclusion The c-reactive protein and plasma fibrinogen can be used as one of the indexes of early diagnosis and disease monitoring of patients with acute exacerbation of chronic obstructive pulmonary disease, and the detection value of c-reactive protein was （8.2±3.62） mg/L.