维吾尔族及汉族患者人腺病毒36感染与肥胖低密度脂蛋白关系研究

Prevalence of adenovirus 36 and its relationship with obesity and low density lipoprotein in people of Uygur and Han nationality

目的了解新疆某三甲医院维吾尔族、汉族患者人腺病毒36(HAd V-36)感染与肥胖、低密度脂蛋白胆固醇(LDL-C)的关系。方法对2013年6月至2014年10月新疆医科大学第一附属医院内科132例维吾尔族、汉族入院检查的患者进行调查,并测定HAd V-36感染率,按体重指数(BMI)、LDL-C水平分组分析。结果BMI<25(正常组)、25≤BMI<28(超重组)、BMI≥28(肥胖组)HAd V-36病毒抗体阳性检出率分别为6.88%、21.87%、36.59%(P<0.05);其中维吾尔族BMI<25、25≤BMI<28、BMI≥28 HAd V-36病毒抗体阳性检出率分别为4.76%、27.78%、36.60%(P<0.05);汉族BMI<25、25≤BMI<28、BMI≥28 HAd V-36病毒抗体阳性检出率分别为7.89%、14.29%、37.50%(P<0.05),但不同的BMI组维族及汉族比较病毒检出率差异无统计学意义(P>0.05)。LDLC<3.37mmol/L、LDL-C≥3.37 mmol/L组HAd V-36病毒抗体阳性检出率分别为12.20%,32%(P<0.05);其中维吾尔族LDL-C<3.37 mmol/L、LDL-C≥3.37 mmol/LHAd V-36病毒抗体阳性检出率分别为15%、37.50%(P<0.05);汉族LDL-C<3.37 mmol/L、LDL-C≥3.37 mmol/LHAd V-36病毒抗体阳性检出率分别为9.52%、26.93%(P<0.05)。但不同的LDL组维族及汉族病毒检出率比较差异无统计学意义(P>0.05)。结论 HAd V-36病毒感染与新疆维吾尔族及汉族肥胖、LDL密切相关,随着BMI指数的增加,HAd V-36病毒检出率越高;且LDL-C水平越高,HAd V-36病毒检出率越高。

Objective To explore the prevalence of adenovirus 36 and its relationship with obesity and low density lipoprotein in people of Uygur and Han nationality in some Xinjiang tertiary referral center. Methods The clinical data was reviewed and the prevalence of adenovirus 36 was detected in 132 patients. They were divided into different groups according to BMI and LDL-C. Results the positive rates of antibodies for adenovirus 36 in BMI≤ 25.0, BMI25.0-28.0 and BMI≥28.0 groups were 6.88%, 21.87%, 36.59% （P〈0.05）, In Uighur group, Adv36 antibody positive rate was 4.76%, 27.78%, 36.60% （P〈0.05）; In Han group, Adv36 antibody positive rate was 7.89%, 14.29%, 37.50% （P〈0.05）. No significant difference between the two nationalities was found （P〉0.05）. The positive rates of antibodies for adenovirus 36 in LDL-C〈3.12mmol/L and LDL-C≥3.12mmo1/L groups was 12.20%, 32% （P〈0.05）. In Uighur group, Adv36 antibody positive rate was 15%, 37.50% （P 〈0.05 ）; In han group, Adv36 antibody positive rate was 9.52%, 26.93% （ P 〈0.05 ） （P〈0.05）, but no significant difference between the two nationalities was found in LDL group （P〉0.05）. Conclusion The prevalence of adenovirus 36 is dosely related to obesity and low density lipoprotein The higher the BMI and LDL, the higher the prevalence of HAdV-36.