拉西地平对老年高血压脉搏传导速度的改善及其与内皮素脂联素的关系研究

Lacidipine treatment for elderly hypertensive patients in improving the ba PWV and its relationship with ET-1 and ADP

目的观察拉西地平对老年高血压的效果及脉搏波传导速度(pulse wave velocity,PWV)的影响与内皮素和脂联素的关系。方法收集100例老年高血压患者,均给于拉西地平片口服,治疗6个月后,观察患者治疗前后动态血压、脉搏波传导速度、血清内皮素和脂联素水平的变化。结果患者经过6个月的治疗后与治疗前相比有显著下降,差异有统计学意义(P<0.05)。患者治疗后的显效、有效和无效的例数分别为32、51和17例,降压总有效率为83%。患者治疗后ba PWV(1578.8±198.7)cm/s较治疗前ba PWV(2025.5±340.9)cm/s有明显下降,差异有统计学意义(P<0.05)。患者的血清内皮素水平由治疗前的(78.24±10.13)pg/L下降至治疗后的(53.41±15.06)pg/L,脂联素水平由治疗前的(3.35±1.13)mg/L上升至治疗后的(7.83±2.34)mg/L,二者前后比较差异均有统计学意义(P<0.05),且内皮素与脂联素水平呈显著负相关(100例,r=-0.488,P=0.000)。结论拉西地平对治疗老年高血压患者有明显疗效,同时具有改善动脉硬化保护血管的作用。

Objective To evaluate the efficacy of lacidipine on blood pressure（BP）and on baPWV in elderly hypertensive patients and to analyze its relationship with ET-1 and ADP. Methods Totally 100 elderly hypertensive patients were collected and treated with lacidipine orally, once daily. After 6 months of treatment, the changes ofABP, baPWV, serum endothelin （ET-1） and adiponectin （ADP） levels were observed. Results Both SBP and DBP were significantly decreased after 6 months of treatment, and there were significant differences（P〈0.05 ）. The total effective rate were 83%. the baPWV （ 1578.8＋ 198.7）cm/s after the treatment compared with the baPWV （2025.5 ± 340.9）cm/s before the treatment significantly reduced, there were statistical significances for the diffenrences （P〈0.05）. Serum ET-1 level was decreased from （78.24±10.13） pg/L to （53.41±15.06） pg/L,ADP level was increased from （3.35 ± 1.13） μg/ml to （7.83 ±2.34） μg/ml, there were statistical significances for both of their diffenrences （P 〈0.05）. Besides, the ADP and ET-1 levels were significantly negatively correlated （n=100,r = -0.488, P = 0.000）. Conclusion While having an obvious effect for on elderly patients with hypertension,lacidipine can improve atherosclerosis and protect blood vessels.