3D-CRT联合DC-CIK细胞治疗高原地区复发性小细胞肺癌的疗效观察

Observation on effect of 3D-CRT combined with DC-CIK cell in treatment of recurrent smell cell carcinoma in high altitude regions

目的探讨三维适型放疗(3D-CRT)联合树突状细胞-细胞因子诱导的杀伤细胞(DC-CIK)回输治疗高原地区复发性小细胞肺癌(SCLC)的临床疗效,以及对血管内皮生长因子(VEGF)、神经元特异性烯醇化酶(NSE)的影响。方法选取2012年5月至2014年4月青海省第五人民医院肿瘤放疗科收治的复发性SCLC患者85例,按随机数字表法分为对照组(41例)与观察组(44例),分别给予单纯3D-CRT治疗,3D-CRT联合DC-CIK细胞治疗,比较两组的疗效、不良反应发生率、治疗前后VEGF及NSE水平,并观察治疗前后两组各项肝、肾功能指标变化。结果观察组的有效率(65.9%)及疾病控制率(79.5%)均高于对照组,差异均有统计学意义(P<0.05)。两组治疗4、8周后,血清VEGF、NSE水平及疼痛评分均下降,差异均有统计学意义(P<0.05);治疗8周后,观察组VEGF、NSE水平及疼痛评分均低于对照组,差异均有统计学意义(P<0.05)。两组各项不良反应发生率比较,差异均无统计学意义(P>0.05)。两组治疗前及治疗后各项肝、肾功能指标水平比较,差异均无统计学意义(P>0.05)。结论 3D-CRT联合DC-CIK细胞生物治疗高原地区复发性SCLC的疗效更明显,且对放(化)疗不良反应及肝、肾功能无明显影响。

Objective To investigate the effect of 3-dimensonal conformal radiotherapy（3D-CRT） combined with dendritic cell cytokine induced kill （DC-CIK） cell in the treatment of recurrent small cell lung carcinoma（SCLC） in high altitude regions,and its influence on VEGF and NSE. Methods Eighty-five patients with recurrent SCLC in the tumor radiotherapy department of the Qinghai Provincial Fifth People＇ s Hospital from May 2012 tO April 2014 were selected and divided into the control group（41 cases） and observation group（44 cases） according to the random number table. The two groups were respectively treated by 3D-CRT treat- ment and 3IYCRT combined with DC-CIK treatment cell. The curative effect, incidence rate of adverse reactions,levels of VEGF and NSE,changes of liver and renal function indexes in the two groups were compared before and after treatment. Results The ef- fective rate and sickness control rate of the observation group were 65.9 ~ and 79.5 ~ respectively, which were higher than those in the control group,and the differences were statistically significant（P〈0.05）. The levels of serum EGF and NSE,and pain score at 4,8 weeks after treatment were decreased,the differences were statistically significant（P〈0.05）. The levels of VEGF and NSE, and pain score at 8 weeks after treatment in the observation group were lower than those in the control group,the differences were statistically significant（P〈0.05）. The incidence rate of adverse reactions in the two groups had no statistically significant differ- ences after treatment（P〈0.05）. The levels of liver and renal function indexes had no statistically significant differences between before and after treatment（P〈0.05）. Conclusion 3D-CRT combined with DC-CIK cell in the treatment of recurrent SCLC in high altitude regions has more obvious curative effect,moreover has no obvious influence on radiotherapeutic adverse reactions,and liver and renal functions.