肺吸入用微粒的粉体工程学技术研究进展

Advances in particle engineering techniques for pulmonary drug delivery

近年来,药物的肺部递送作为一种非侵入性的给药途径引起了广泛关注,肺部给药的市场需求也不断增加。各种粉体工程学技术被用于开发具有合适物理性质的用于肺部递送的药物颗粒,这些经过设计的药物颗粒为高效的肺部递送和最优的治疗效果提供了可能。本文重点阐释了肺部颗粒的沉积机制以及各种粉体工程技术在肺部给药领域中的应用,其中Pulmo Sphere^(TM)和Techno Sphere^(TM)两种新技术已用于上市产品的生产。

In recent years,pulmonary drug delivery as an attractive non-invasive administration way has been gaining intensive attention. The market for inhalable therapy has constantly grown over past years. Various particle engineering techniques have been employed to exploit the drug particles or drug-loaded particles used for pulmonary delivery with suitable physical properties.Those tailor-made inhalable particles offer the possibility of efficient delivering to lungs and the most optimal therapeutic outcomes.This review highlights the deposition mechanism of particles in lungs and several particle engineering techniques for pulmonary drug delivery,in particular two novel techniques Pulmo Sphere^（TM） and Techno Sphere^（TM）,which have been used in the marketed products。