诱导多能干细胞与心脏再生

Induced pluripotent stem cells in cardiac regeneration

诱导多能干细胞(induced pluripotent stem cells,i PSCs)研究的快速发展为心血管转化医学研究领域提供了新的策略.诱导多能干细胞不仅具有与胚胎干细胞类似的多能性,且巧妙地回避了胚胎干细胞面临的伦理学问题和免疫排斥反应.心肌细胞等成体心血管细胞在发生心血管疾病后增殖能力有限,而i PSCs来源的心血管细胞在心脏再生治疗中颇具应用前景,是理想的细胞来源,因此在基础医学和转化医学研究领域受到广泛关注.就i PSCs的发展过程及其在心脏再生中的应用作一综述,并探讨目前i PSCs在心脏再生临床转化中亟待解决的问题.

Induced pluripotent stem cells （iPSCs） have emerged as a novel tool for cell therapy for cardiovascular diseases, iPSCs are functionally similar to embryonic stem cells （ESCs） while avoiding ethical issues and immune rejection. Given limited regenerative ability of human heart following cardiovascular diseases cardiovascular cells derived from iPSCs have been considered as a promising cell source in cardiovascular regenerative therapy. This paper summarizes and discusses the iPSCs technology and its potential regenerative applications in cardiac regeneration.