中药提取物声敏剂在声动力治疗动脉粥样硬化中的应用

Application of sonosensitizers derived from Chinese herb products in sonodynamic therapy for atherosclerosis treatment

目前,动脉粥样硬化引起的心血管疾病发生率越来越高,除昂贵的介入和搭桥治疗术外,寻求一种简单、有效且经济的治疗方法至关重要.声动力治疗是一种无创、安全的治疗方式,其在动脉粥样硬化治疗中的应用很有前景.声动力治疗中使用的药物为声敏剂,是影响其疗效的主要因素之一.研究人员一直致力于探讨不同种类声敏剂所带来的声动力效果在动脉粥样硬化治疗中起到的不同作用.近年来,在声敏剂的筛选研究中发现,中药提取物有很大的潜在声敏剂价值.简要总结了目前对声动力治疗机制及大黄素、姜黄素及其衍生物和金丝桃素作为声敏剂在声动力治疗动脉粥样硬化中的相关进展.

At present, morbidity of cardiovascular disease induced by atherosclerosis （AS） is becoming higher. Besides expensive intervention and bypass surgery, it is extremely urgent to look for a popular and effective method for the treatment of AS. Sonodynamic therapy （SDT） is a non-invasive targeting therapy, and is promising for AS treatment based on the SDT-related research. Sonosensitizer, an application of SDT, is an entry points of the SDT investigation. Therefore, different sonodynamic effects with different sonosensitizers are investigated by researchers in AS treatment. In recent years, it is found that sonosensitizers derived from Chinese herb products play an important role in SDT, exerting potent sonodynamic effects for AS treatment. This review briefly summarizes the action of SDT and relevant development of SDT with emodin, curcumin, hypericin and its derived derivatives as sonosensitizers for AS treatment.