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转录因子Bach1在心血管疾病中的研究进展 被引量：1

Advances of transcription factor Bach1 in cardiovascular diseases
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摘要 转录因子Bach1(BTB-CNC同源体1,BTB and CNC homology 1)是一种转录抑制因子,广泛存在于哺乳动物的各种组织中.Bach1能抑制血红素环氧化酶-1(heme oxygenase-1,HO-1)等抗氧化基因的表达,参与氧化应激反应.Bach1基因敲除对心肌缺血再灌注损伤有保护作用.近期研究发现Bach1能抑制Wnt/β-catenin信号通路和小鼠缺血下肢血管新生.主要就Bach1在心血管疾病中的研究进展进行简要综述. BTB and CNC homology 1 （Bach1） is a transcription factor widely existing in most tissues of mammals. Bach1 negatively regulates various antioxidant gene such as heine oxygenase-1 （HO-1）, involving oxidative stress. Knockout of Bachl has a protective effect on myocardial ischemia reperfusion injury. Recent research found that Bachl inhibits the Wnt/β-catenin signaling pathway and angiogenesis in hindlimb ischemia of mice. This paper focuses on the research of Bach1 in cardiovascular diseases.
作者 贾孟萍 郭阶雨 孟丹
机构地区 复旦大学基础医学院生理与病理生理学系
出处 《上海大学学报（自然科学版）》 CAS CSCD 北大核心 2016年第3期326-330,共5页 Journal of Shanghai University:Natural Science Edition
基金 国家自然科学基金资助项目(81170298 81270410)
关键词 Bach1 心血管疾病 血管新生 WNT信号 Bach1 cardiovascular disease angiogenesis Wnt signal
分类号 R363.2 [医药卫生—病理学]
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参考文献21

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  • 2Yoshida C, Tokumasu F, Hohmura K I, et al. Long range interaction of cis-DNA elements mediated by architectural transcription factor Bach1 [J]. Genes Cells, 1999, 4(11): 643-655.
  • 3Ogawa K, Sun J, Taketani S, et al. Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1 [J]. EMBO J, 2001, 20(11): 2835-2843.
  • 4Suzuki H, Tashiro S, Hira S, et al. Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1 [J]. EMBO J, 2004, 23(13): 2544-2553.
  • 5Dhakshinamoorthy S, Jain A K, Bloom D A, et al. Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H: quinone oxidoreductase 1 gene expression and induction in response to antioxidants [J]. J Biol Chem, 2005, 280(17): 16891-16900.
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二级参考文献18

  • 1Yla-Herttuala S. Cardiovascular gene therapy with vascular endothelial growth factors [ J ]. Gene, 2013, 525 (2) : 217-219.
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  • 3Okita Y, Kamoshida A, Suzuki H, et al. Transforming growth factor-beta induces transcription factors MafK and Bachl to suppress expression of the heme oxygenase-1 gene[J]. J Bid Chem, 2013, 288(28) :20658-20667.
  • 4Niture SK, Khatri R, Jaiswal AK. Regulation of Nrt2-an update[J]. Free Radic Biol Med, 2014, 66(1) :36-44.
  • 5Meng D, Wang X, Chang Q, et al. Arsenic promotes an- giogenesis in vitro via a heme oxygenase-1-dependent mechanism[ J ]. Toxicol Appl Pharmacol, 2010, 244 (3) : 291-299.
  • 6Shao R, Guo X. Human microvascular endothelial cells immortalized with human telomerase catalytic protein: a model for the study of in vitro angiogenesis [ J ]. Biochem Biophys Res Commun, 2004, 321 (4) :788-794.
  • 7Meng D, Mei A, Liu J, et al. NADPH oxidase 4 mediates insulin-stimulated HIF-lalpha and VEGF expression, and angiogenesis in vitro [ J ]. PLoS One, 2012, 7 ( 10 ) : e48393.
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  • 9Warnatz H J, Schmidt D, Manke T, et al. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle [J]. J Biol Chem, 2011,286(26) :23521-23532.
  • 10Yano Y, Ozono R, Oishi Y, et al. Genetic ablation of the transcription repressor Bach1 leads to myocardial protec- tion against ischemia/reperfusion in mice [ J ]. Genes Cells, 2006, 11 (7) :791-803.

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上海大学学报（自然科学版）
2016年 第3期

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