涎腺腺样囊性癌中上皮间充质转化分子调控机制的研究进展

Research progress on the mechanism of epithelial-mesenchymal transition in salivary adenoid cystic carcinoma

涎腺腺样囊性癌(SACC)是最常见的涎腺恶性肿瘤之一,具有嗜神经侵袭和肺高转移特性,虽然生长缓慢,但其侵袭性强,预后差。近年来国内外学者对SACC发生上皮间充质转化(EMT)进行了大量的研究,以期探讨SACC发生发展、侵袭和远处转移的机制,启发临床治疗新思路。本文就SACC中EMT发生机制的研究进展作一综述。

Salivary adenoid cystic carcinoma（SACC） is one of the most malignant tumors in salivary adenoid tissue with a feature of perineural invasion, lung metastasis, which grows slowly but easily trends to invasion and has a poor prognosis. In recent years domestic and foreign scholars have done a lot of researches about epithelial-mesenchymal transition（EMT） in SACC, for revealing the mechanism of its development, invasion and metastasis and exposing new therapy. This review elucidated the EMT mechanism in SACC.