摘要
涎腺腺样囊性癌(SACC)是最常见的涎腺恶性肿瘤之一,具有嗜神经侵袭和肺高转移特性,虽然生长缓慢,但其侵袭性强,预后差。近年来国内外学者对SACC发生上皮间充质转化(EMT)进行了大量的研究,以期探讨SACC发生发展、侵袭和远处转移的机制,启发临床治疗新思路。本文就SACC中EMT发生机制的研究进展作一综述。
Salivary adenoid cystic carcinoma(SACC) is one of the most malignant tumors in salivary adenoid tissue with a feature of perineural invasion, lung metastasis, which grows slowly but easily trends to invasion and has a poor prognosis. In recent years domestic and foreign scholars have done a lot of researches about epithelial-mesenchymal transition(EMT) in SACC, for revealing the mechanism of its development, invasion and metastasis and exposing new therapy. This review elucidated the EMT mechanism in SACC.
出处
《国际口腔医学杂志》
CAS
北大核心
2016年第4期421-427,共7页
International Journal of Stomatology
基金
国家自然科学基金(81272961
81572650)~~
关键词
腺样囊性癌
上皮间充质转化
调控机制
salivary adenoid cystic carcinoma
epithelial-mesenchymal transition
regulating mechanism