酸枣百合汤治疗血亏阴虚型更年期失眠临床疗效观察

Clinical Curative Observation of Using Suanzao Baihe Decoction in the Treatment of Menopause Insomnia with Blood and Yin Deficiency Type

目的：观察自拟酸枣百合汤对血亏阴虚型更年期失眠的临床疗效。方法选择2012年12月至2014年12月来我院就诊的更年期失眠症患者120例,中医症候符合血亏阴虚型。以随机数字表法分为观察组和对照组,每组60例。观察组给予自拟酸枣百合汤治疗,每日3次;对照组给予艾司唑仑片（1~2mg/晚）治疗。两组疗程均为6周。采用匹兹堡睡眠指数量表评价患者治疗第6周后的临床疗效并记录不良反应。结果：治疗6周后,两组患者睡眠质量均有明显改善,但是观察组比对照组改善更为明显,差异有统计学意义（P〈0.05）。对照组失眠症状改善的总有效率为65.0%,而观察组则达到86.7%,明显高于对照组,差异有统计学意义（P〈0.05）。结论：口服酸枣百合汤治疗血亏阴虚型更年期失眠症疗效显著,可显著缓解失眠症状。

Objective： To observe the clinical efficacy of using Self-designed Suanzao Baihe Decoction in the treatment of menopause insomnia with Blood and Yin deficiency type. Methods： From December 2012 to December 2014,120 cases of menopause insomnia patients with deficiency of Blood and Yin were chosen for the study. All patients were divided into observation group and controlled group with 60 cases in each group. The observation group was treated with Self-designed Suanzao Baihe Decoction,3 times per day; the controlled group was given Estazolam tablets（ 1-2 mg / day）. All patients were treated for 6 weeks.The clinical efficacy was evaluated with Pittsburgh Sleep Index and adverse reactions were recorded. Results： After 6 weeks of treatment,the sleep quality of the two groups were significantly improved,but the observation group was better than the controlled group,and the difference was statistically significant（ P〈0. 05）. In the controlled group,the total effective rate was65%,while the observation group reached 86. 7%,which was significantly higher than that of the controlled group,and the difference was statistically significant（ P〈0. 05）. Conclusion： Orally taking Suanzao Baihe Decoction can effectively cure menopause insomnia with Blood and Yin deficiency and significantly relieve the symptoms of insomnia.