35例脊髓损伤患者神经干细胞移植临床疗效研究

Research on Clinical Curative Effect of Neural Stem Cells Transplantation in Treatment of 35 Cases with Spinal Cord Injury

目的探讨和分析应用神经干细胞移植法来治疗脊髓损伤所取得的疗效状况。方法方便选取2013年12月—2015年1月期间该院收治的35例脊髓损伤患者为研究对象,应用脊髓探查和损伤局部神经干细胞移植结合的手术方法进行治疗,然后通过ASIA评分系统对患者手术之前与手术之后6个月评定神经功能情况。结果经过手术后6个月,患者的运动、痛觉和轻触觉等ASIA总评分为(177.47±77.02)分,明显高于手术前(145.09±63.15),手术前后的ASIA总评分对比,差异具有统计学意义(t=5.827,P<0.05)。结论采取神经干细胞移植的治疗方法 ,能够使脊髓受到损伤的患者在运动、感觉等多个方面的神经功能得到显著的改善,有利于患者康复及生活质量的提高。

Objective To discuss and analyze the curative effect of neural stem cells transplantation in treatment of spinal cord injury. Methods 35 cases of patients with spinal cord injury admitted and treated from December 2013 to January 2015 were selected as the research object, and they were treated with the operative method of spinal cord exploration com- bined with injured local neural stem ceils transplantation, and then the neural function conditions were evaluated by the A- SIA marking system before operation and at sixth month after operation. Results The total ASIA score including motor, pain and light touch sensation at sixth month after operation was obviously higher than that before treatment, [（177.47±77.02） marks vs（145.09±63.15） marks], the difference in the total ASIA score before operation and after operation was obvious with statistical significance,（t=5.827, P〈0.05）. Conclusion The treatment method of neural stem ceils transplantation can obvi- ously improve the multiple-aspect neural functions including motor and sensation in patients with spinal cord injury, and it is conducive to the recovery and improvement of quality of life of patients.