尿激酶溶栓治疗急性期脑梗死患者疗效分析

Analysis of Curative Effect of Urokinase in Treatment of Patients with Acute Cerebral Infarction

目的探讨超早期急诊尿激酶溶栓治疗脑梗死的临床疗效。方法整群选取2015年1—10月该院急诊科室接待的急性脑梗死患者共98例,将入选患者用数字随机分组形式均分为实验组及对照组,每组49例。其中对照组患者在降低颅内压、促进脑功能恢复及抗血小板聚集等治疗基础上给予静脉滴注低分子肝素钠治疗,实验组患者于常规治疗基础上给予尿激酶溶栓治疗,对比观察两组患者治疗效果及各项相关指标的变化情况。结果治疗后,实验组患者总有效率为(91.9%),明显高于对照组患者(55.1%),差异具有统计学意义(P<0.05);实验组患者NIHSS评分及BI评分均明显优于对照组患者,差异有统计学意义(P<0.05);治疗后,实验组患者各项血液流变学指标改善明显优于对照组患者,差异具有统计学意义(P<0.05)。结论早期急诊尿激酶溶栓治疗急性脑梗死患者效果显著,对患者临床症状及预后改善效果明显,值得于临床进一步推广使用。

Objective To discuss the clinical curative effect of ultra-early emergency intravenous thrombolysis with uroki- nase in treatment of cerebral infarction.Methods 98 cases of patients with acute cerebral infarction treated in the depart- ment of emergency of our hospital from January 2015 to October 2015 were selected and randomly divided into two groups with 49 cases in each, the control group were treated with the intravenous drip of heparinum natricum minor molecularis onthe basis of decreasing intracranial pressure, promote the recovery of cerebral function and anti-platelet aggregation, the ex- perimental group were treated with thrombolysis with urokinase on the basis of conventional treatment, the treatment effects and changes of various relevant indexes of the two groups were compared and observed. Results After treatment, the total effective rate in the experimental group was obviously higher than that in the control group, （91.9% vs 55.1%）, and the dif- ference had statistical significance, P〈0.05, the NIHSS score and BI score in the experimental group were obviously better than those in the control group, and the differences had statistical significance, P〈0.05, after treatment, the improvement of various indexes of hemorheology in the experimental group was obviously better than that in the control group, and the dif- ference had statistical significance, P〈0.05. Conclusion The effect of early emergency intravenous thrombolysis with uroki- nase in treatment of patients with acute cerebral infarction is obvious, which can obviously improve the clinical symptoms and prognoses of patients, and it is worth clinical further promotion and application.