激素联合环磷酰胺治疗间质性肺疾病及对患者血清白介-6水平的影响

Hormone Combined with Cyclophosphamide in Treatment of Interstitial Lung Disease and Its Effect on Serum Interleukin-6 in Patients

目的探讨激素联合环磷酰胺治疗间质性肺疾病对患者血清白介-6水平的影响。方法选取该院2014年3月—2015年7月间收治的120例间质性肺疾病患者随机分组,观察组60例给予激素联合环磷酰胺治疗,对照组60例单纯给予激素治疗,比较两组患者治疗前后FEV1、FVC、FVC(%)、DLCO、DLCO(%)、HRCT评分、IL-6水平。结果两组患者治疗前FEV1、FVC、FVC(%)、DLCO、DLCO(%)、HRCT评分、IL-6水平比较差异无统计学意义(P>0.05);观察组治疗后FEV1、FVC、FVC(%)、DLCO、DLCO(%)、HRCT评分、IL-6水平与对照组比较差异有统计学意义(P<0.05)。结论激素联合环磷酰胺治疗间质性肺疾病效果显著,能降低患者血清白介-6水平,缓解患者临床症状。

Objective To discuss the hormone combined with cyclophosphamide in treatment of interstitial lung disease and its effect on serum interleukin-6 in patients. Methods 120 cases of patients with interstitial lung disease treated in our hospital from March 2014 to July 2015 were randomly divided into two groups with 60 cases in each, the observation group were treated with hormone combined with cyclophosphamide, the control group were treated with simple hormone, and the FEV1, FVC, FVC（%）, DLCO, DLCO（%）, HRCT scores and IL-6 levels before and after treatment were compared between the two groups. Results There was no obvious difference in the FEV1, FVC, FVC（%）, DLCO, DLCO（%）, HRCT score and IL-6 level between the two groups before treatment（P〉0.05）, there were obvious differences in the FEV1, FVC, FVC（%）,DLCO, DLCO（%）, HRCT score and IL-6 level between the two groups after treatment（P〈0.05）. Conclusion The effect of hormone combined with cyclophosphamide in treatment of interstitial lung disease is obvious, which can reduce the serum interleukin-6 level and relieve the clinical symptoms of patients.