急性CO中毒迟发性脑病患者早期血浆HMGB1的表达与预后

Expression and Prognosis of Early Plasma HMGB1 for Patients with DNS in Acute CO Poisoning

目的探讨急性一氧化碳(CO)中毒迟发性脑病患者血浆高迁移率族蛋白B1(HMGB1)的表达与预后。方法回顾性分析2012年1月—2015年1月该院接收的最终确诊为急性CO中毒迟发性脑病患者10例,另选取同时期内急性CO中毒患者10例以及健康体检者10例作为对照组。分别对各组患者的血浆HMGB1水平进行检测。另外,分别采用日常生活能力量表(ADL)、常识-记忆-注意测验(IMCT)、长谷川痴呆量表(HDS)分析急性CO中毒迟发性脑病患者血浆HMGB1水平变化及与量表评分之间的关系。结果 CO中毒迟发性脑病患者急性期血浆HMGB1水平为(14.23±10.32)ng/m L,明显高于恢复期的(7.93±4.99)ng/m L,差异有统计学意义(t=2.653,P<0.05);CO中毒迟发性脑病组急性期、恢复期血浆HMGBl水平与HDS以及ADL评分呈现显著正相关(r=0.610;r=0.605;r=0.607;r=0.610,P<0.05)。结论 HMGBl参与急性CO中毒迟发性脑病的炎症反应前过程,且与HDS以及ADL评分呈正相关。

Objective To discuss the expression and prognosis of early plasma HMGB1 for patients with DNS in acute CO poisoning. Methods 10 cases of patients with DNS in acute CO poisoning were retrospectively analyzed. At the same time,another 10 cases of patients with acute CO poisoning and 10 cases of healthy people were selected as the control group. The plasma HMGB1 levels of patients in each group were detected. In addition, ADL, IMCT, and HDS were used to analyze the relationship between HMGB1 level change and scale rating for patients with delayed encephalopathy in acute CO poisoning.Results In acute stage and recovery stage, the HMGB1 level of CO poisoning DNS group is in positive correlation with HDS and ADL score（P 〈 0.05）. Conclusion HMGB1 participated in the process of patients with DNS, and is in positive correlation with HDS and ADL scores.