小剂量右美托咪啶控制高血压患者血压的临床效果及安全性分析

Analysis of Clinical Effect and Safety of Small-dose Dexmedetomidine in Controlling the Blood Pressure in Patients with Hypertension

目的探讨小剂量右美托咪啶控制高血压患者血压的临床效果及安全性。方法整群选取2014年1—12月该院收治的高血压患者84例,按照数字表法随机分为研究组和对照组,其中对照组给予咪达唑仑静脉滴注麻醉,研究组给予右美托咪啶静脉泵注。结果研究组患者的脉搏血氧饱和度水平(97.26±0.82)%明显高于对照组(88.25±1.22)%(t=3.25,P<0.05),而血压及心率则无明显差异。研究组的不良反应发生率(11.90%)与对照组(26.19%)相比差异无统计学意义(χ2=2.78,P>0.05)。结论小剂量右美托咪啶可以有效控制高血压患者围术期的血压,且不良反应少。

Objective To discuss the clinical effect and safety of small-dose dexmedetomidine in controlling the blood pressure in patients with hypertension. Methods The patients with hypertension admitted and treated from January 2014 to December 2014 were randomly divided into two groups, the control group were given intravenous drip of midazolam for anesthesia, and the research group were given intravenous infusion of dexmedetomidine. Results The pulse blood oxygen saturation in the research group was obviously higher than that in the control group, [（97.26 ±0.82%） vs（88.25±1.22%）],（t=3.25,P〈0.05）, but there was no obvious difference in the blood pressure and heart rate, and there was no obvious difference in the incidence rate of adverse reactions between the research group and the control group,（11.90% vs 26.19%）,（χ2=2.78, P〉0.05）. Conclusion Small-dose dexmedetomidine can effectively control the blood pressure of patients with hypertension in the perioperative period and there were fewer adverse reactions.