亚低温治疗中重度新生儿缺氧缺血性脑病临床探讨

Clinical Experience of Mild Hypothermia in Treatment of Severe Newborns with Hypoxic-ischemic Encephalopathy

目的探讨亚低温应用于重度新生儿缺氧缺血性脑损伤治疗中的临床效果。方法探讨选取2014年1月—2015年1月期间,该院收治的中重度缺氧缺血性脑病新生儿62例,随机分为对照组与观察组,各31例,对照组患儿采用常规治疗,观察组患儿采用亚低温方式治疗,观察两组患儿的临床治疗效果。结果治疗后,观察组患儿在治疗的总有率为93.5%,治疗72 h后,患者的心率、血压以及呼吸分别为(124±11)、(40±12)、(54±7)、(34±70),后遗症发生率为6.4%,对照组患儿在治疗的总有率为80.6%,治疗72 h后,患者的心率、血压以及呼吸分别为(129±7)、(35±9)、(49±6)、(29±60)后遗症发生率为19.3%,观察组各项指标均显著优于对照组(P<0.05)。结论亚低温在重度新生儿缺氧缺血性脑病临床治疗中效果显著,且安全性高,值得在临床上推广和应用。

Objective To study the clinical effect of mild hypothermia in treatment of severe newborns with hypoxic-ischemic encephalopathy. Methods 62 cases of severe newborns with hypoxic-ischemic encephalopathy admitted and treated in our hospital from January 2014 to January 2015 were selected and randomly divided into two groups with 31 cases in each, the control group were treated with the conventional method, the observation group were treated with the mild hypothermia method, and the clinical treatment effects of the two groups were observed. Results After treatment, the total treatment effective rate was 93.5% in the observation group and 80.6% in the control group, after 72 h treatment, the heart rate, blood pressure, respiration and incidence rate of sequelae were respectively（124 ±11）,（40 ±12）,（54 ±7）,（34 ±70） and6.4% in the observation group and（129±7）,（35±9）,（49±6）,（29±60） and 19.3%, and various indexes in the observation group were obviously better than those in the control group（P〈0.05）. Conclusion The effect of mild hypothermia in clinical treatment of severe newborns with hypoxic-ischemic encephalopathy is obvious with high safety, which is worth clinical promotion and application.