雷公藤多苷联合吗替麦考酚酯治疗老年IgA肾病疗效观察

Observation on Curative Effect of Tripterygium Glycosides and Mycophe-nolate Mofetil in Treatment of Elderly IgA Nephropathy

目的为了进一步提高老年IgA肾病患者的临床治疗效果,分析和探讨临床同时应用雷公藤多苷和吗替麦考酚酯治疗的安全性和有效性。方法通过随机双盲对照的方法选取60例于2014年2月—2015年2月期间来该院老年科就诊的IgA肾病患者作为研究对象并分为对照组和观察组各30例,其中观察组患者在治疗方案上选取吗替麦考酚酯联合雷公藤多苷治疗,而对照组患者在治疗方案上选取单用吗替麦考酚酯治疗,比较不同治疗方案的疗效差异。结果经过统计分析发现,观察组患者的治疗总有效率为28例(93.33%),对照组患者为24(80.00%),观察组患者显著优于对照组患者,差异有统计学意义(χ2=3.482,P<0.05),对照组和观察组患者的病情均得到了控制,但是观察组的治疗效果明显优于对照组。结论雷公藤多苷和吗替麦考酚酯联合用药控制IgA肾病病情临床治疗效果显著,且安全可靠,值得临床推广。

Objective To analyze and discuss the safety and effectiveness of tripterygium glycosides and mycophenolate mofetil treatment in order to further improve the clinical treatment effect for patients with elderly IgA nephropathy.Methods 60 cases of elderly patients with IgA nephropathy diagnosed in the department of geratology of our hospital from February 2014 to February 2015 were randomly selected as the research objects and divided into two groups with 30 cases in each, the observation group were treated with tripterygium glycosides and mycophenolate mofetil, while the control group were treated with simple mycophenolate mofetil, and the difference in the curative effect of different treatment programs were compared. Results The statistical analysis discovered that the total treatment effective rate in the observation group was obviously better than that in the control group with statistical difference（93.33% vs 80.00%）,（28 cases vs 24 cases）,（χ2=3.482, P〈0.05）, the disease conditions of both groups were controlled, but the treatment effect in the observation group was obviously better than that in the control group. Conclusion The clinical curative effect of tripterygium glycosides and mycophenolate mofetil in treatment of elderly IgA nephropathy is obvious, and it is safe and reliable, which is worth clinical promotion.