中医药分阶段结合化疗治疗晚期非小细胞肺癌的临床研究

Clinical Research on Staged Chinese Herbal Medicinal Therapy Combined with Chemotherapy in Treatment of Advanced Non-small Cell Lung Cancer

目的探讨中医药分阶段结合化疗治疗晚期非小细胞肺癌的临床效果。方法纳入的对象为整群选取该院自2011年1月—2013年1月所收治的77例晚期非小细胞肺癌患者,随机分为化疗组、化疗+中医组,观察治疗效果和不良反应等指标。结果 (1)化疗+中医组患者临床缓解率72.50%跟化疗组67.57%相似,经χ2检验,P>0.05;(2)治疗后化疗+中医组VEGF、CEA、CYFRA21-1、KPS评分、中位生存期更佳,经t检验,P<0.05,其中,化疗组中位生存期为(10.97±2.72)个月,化疗+中医组为(14.91±2.63)个月。(3)化疗+中医组不良反应发生率显著低于化疗组,χ2检验显示P<0.05。其中,化疗组恶心呕吐15例、腹泻6例、血红蛋白减少4例、骨髓抑制4例。化疗+中医组恶心呕吐7例、腹泻2例、血红蛋白减少2例、骨髓抑制2例。结论中医药分阶段结合化疗治疗晚期非小细胞肺癌的临床效果确切,值得推广。

Objective To observe the clinical effect of staged Chinese herbal medicinal therapy combined with chemotherapy in treatment of advanced non-small cell lung cancer. Methods 77 cases of patients with advanced non-small cell lung cancer admitted and treated in our hospital from January 2011 to January 2013 were selected and randomly divided into the chemotherapy group and the chemotherapy plus Chinese medicine group, and the indexes including the treatment effect and the side effect were observed. Results（1） The clinical remission rate of the chemotherapy plus Chinese medicine group was similar to that of the chemotherapy group（72.50% vs 67.57%）, P〉0.05（2） After treatment, the VEGF, CEA, CYFRA21-1and KPS scores and median survival time in the chemotherapy plus Chinese medicine group were better, P〈0.05, the median survival time was（10.97 ±2.72） months in the chemotherapy group and（14.91 ±2.63） months in the chemotherapy plus Chinese medicine group.（3） The incidence rates of toxic and side effects in the chemotherapy plus Chinese medicine group were obviously lower than those in the chemotherapy group, P〈0.05. Nausea and vomiting occurred to 15 cases, diarrhea occurred to 6 cases, decrease in hemoglobin occurred to 4 cases and myelosuppression occurred to 4 cases in the chemotherapy group and nausea and vomiting occurred to 7 cases, diarrhea occurred to 2 cases, decrease in hemoglobin occurred to 2cases and myelosuppression occurred to 2 cases in the chemotherapy plus Chinese medicine group. Conclusion The clinical effect of staged Chinese herbal medicinal therapy combined with chemotherapy in treatment of advanced non-small cell lung cancer is definite, which is worth promotion.