摘要
目的评价左氧氟沙星注射液临床ADR和相关危险因素,提高临床用药安全。方法整群选取并回顾性分析2014年1月—2015年6月间的2 147份应用左氧氟沙星注射液的临床病例资料,统计ADR发生率,采用单因素χ^2检验和多因素Logistics回归分析筛选ADR的危险因素。结果 45例发生ADR,发生率为2.10%。多因素Logistics回归分析年龄（〉65岁）（OR=1.352,95%CI 1.258-1.453）、用药疗程（〉7 d）（OR=1.528,95%CI 1.316-1.774）、用药剂量（〉400 mg）（OR=3.365,95%CI 1.982-5.713）、联合用药（联合≥2种）（OR=2.856,95%CI 1.639-3.234）和联合用药（联合1种）（OR=1.386,95%CI 1.203-1.597）是ADR的危险因素。结论左氧氟沙星ADR发生率相对较高,并且与年龄、用药剂量、疗程和联合用药情况有关。
Objective To evaluate the clinical ADR and relevant factors of levofloxacin injection and improve the clinical medication safety.Methods The clinical data of 2147 cases applying levofloxacin injection from January 2014 to June 2015 were retrospectively analyzed,and the incidence rate of ADR was counted,and the ADR risk factors were screened by the single-factor χ^2detection and multiple-factor Logistics regression analysis.Results ADR occurred to 45 cases and the incidence rate was 2.10%,the multiple-factor Logistics regression analysis showed that the age（65 years old）（OR=1.352,95% CI 1.258-1.453）,course of treatment（〉7 d）,（OR=1.528,95% CI 1.316-1.774）,medication dosage,（〉400 mg）（OR=3.365,95% CI 1.982-5.713）,combined medication,（combined ≥2）（OR=2.856,95% CI 1.639-3.234） and combined medication（combined with 1）（OR=1.386,95% CI 1.203-1.597） were the risk factors of ADR.Conclusion The incidence rate of levofloxacin ADR is relatively higher,and it is correlated with the age,medication dosage,course of treatment and combined medication.
出处
《中外医疗》
2016年第15期70-72,共3页
China & Foreign Medical Treatment
