联合检测血清同型半胱氨酸及幽门杆菌感染在急性脑梗死诊治中的价值探讨

To Investigate the Value of Combined Detection of Serum Homocysteine and Helicobacter Pylori Infection in Diagnosis and Treatment of Acute Cerebral Infarction

目的探讨联合检测血清同型半胱氨酸及幽门杆菌感染对急性脑梗死(ACI)诊治的作用。方法方便选取2013年10月—2015年10月在该院神经科住院治疗的ACI患者150例纳入病例组,并根据是否存在Hp感染分为Hp感染组(n=115)和非Hp感染组(n=35)。另外收集同期在该院进行体检的健康人员100例作为对照组。比较病例组和对照组的Hp阳性检出情况。对比Hp感染组和非Hp感染组血清Hcy、CRP和血脂指标(TC、TG、LDL-C)情况。分析ACI患者血清Hcy与Hp感染的关系。结果病例组、对照组的Hp阳性检出率分别为76.7%、44.0%;病例组的Hp阳性检出率明显高于对照组(P<0.05)。Hp感染患者血清Hcy、CRP、TC、TG、LDL-C、HDL-C水平分别为(27.4±5.9)μmol/L、(7.9±2.2)mg/L、(6.3±0.8)mmol/L、(3.1±0.7)mmol/L、(3.6±0.8)mmol/L、(1.1±0.2)mmol/L,对照组分别为(18.5±5.3)μmol/L、(3.5±1.1)mg/L、(5.2±0.7)mmol/L、(2.3±0.8)mmol/L、(2.8±0.7)mmol/L、(1.9±0.3)mmol/L,Hp感染患者血清Hcy、CRP、TC、TG、LDL-C明显高于Hp非感染患者,HDL-C水平明显低于Hp非感染患者(P<0.05)。ACI患者中,高Hcy血症发生率与Hp感染率有明显正相关性(r=0.562,P=0.00)。结论联合检测Hp感染及Hcy含量利于ACI病情及预后的评估,指导临床治疗方案的制定。

Objective To investigate the effect of diagnosis and treatment combined detection of serum homocysteine（Hcy）and Helicobacter pylori（Hp） infection in diagnosis and treatment of acute cerebral infarction（ACI）. Methods Convenient selection 150 patients with ACI who were hospitalized in neurology department of our hospital from Oct,2013 to Oct,2015 were included into patients group, according to the presence of Hp infection,theye were divided into Hp infected group（n=115） and non Hp infection group（n=35）. In addition,100 healthy people who were done medical examination in our hospital were collected as control group.the Hp positive detection were compared between the patients group and control group. The serum Hcy, CRP and blood lipid index（TC, TG, LDL-C） were compared between Hp infection group and non Hp infection group. The relationship between serum Hcy and Hp infection of patients with ACI were analyzed. Results The Hp positive rate in patient group and in control group was respectively 76.7%、44.0%;the Hp positive rate in patient group was significantly higher than that in control group（P〈0.05）. the serum Hcy, CRP, TC, TG, LDL-C levels of patients with Hp infection were respectively（27.4±5.9）μmol/L、（7.9±2.2）mg/L、（6.3±0.8）mmol/L、（3.1±0.7）mmol/L、（3.6±0.8）mmol/L、（1.1±0.2）mmol/L,those of patients without Hp infection were respectively（18.5±5.3）μmol/L、（3.5±1.1）mg/L、（5.2±0.7）mmol/L、（2.3±0.8）mmol/L、（2.8±0.7）mmol/L、（1.9±0.3）mmol/L, the serum Hcy, CRP, TC, TG, LDL-C levels of patients with Hp infection were significantly higher than those of patients without Hp infection,the HDL-C levels were significantly lower than that of patients without Hp infection（P〈0.05）. In ACI patients, the incidence of serum high Hcy has obvious positive correlation with Hp infection rate（r=0.562, P=0.00）. Conclusion Combined detection of Hp infection and the content of Hcy can help to evaluate the condition and prognosis of ACI,to guid clinical treatment planning.