大剂量氯吡格雷对冠心病不稳定型心绞痛患者介入治疗的疗效观察

Efficacy of High Dose of Clopidogrel on the Interventional Therapy for Pa-tients with Unstable Angina Pectoris

目的探讨大剂量氯吡格雷对冠心病不稳定型心绞痛患者行介入治疗的疗效,以丰富临床经验。方法整群选取2015年6月—2015年12月在该院收治的冠心病不稳定型心绞痛患者110例,根据入院治疗顺序分成对照组与观察组各55例,介入治疗前后对照组给予标准量氯吡格雷治疗,观察组则使用大剂量氯吡格雷。统计两组的临床疗效、血小板聚集率、不良反应发生情况等,并进行对比。结果治疗后观察组的有效率为98.18%,显著优于对照组78.18%,差异有统计学意义(P<0.05);观察组的血小板聚集率为(25.1±3.0)%显著低于对照组(34.9±5.9)%,差异有统计学意义(P<0.05);观察组的不良反应发生率为5.45%,对照组为7.27%,观察组的不良反应发生率低于对照组,差异无统计学意义(P﹥0.05)。结论应用大剂量氯吡格雷对冠心病不稳定型心绞痛患者介入治疗临床疗效显著,使血小板聚集率降低,且具有更高的安全性,值得推广。

Objective To study the efficacy of high dose of clopidogrel on the interventional therapy for patients with unstable angina pectoris（UAP）,so as to enrich clinical experience. Methods Group selection a total of 110 hospitalized patients with UAP who underwent percutaneous coronary intervention（PCI） from June 2015 to Dec 2015 were randomly divided into the control group and the observation group, 55 patients in each group. The control group were treated with the standard dose of clopidogrel and the observation group with high dose of clopidogrel before and after PCI. The clinical efficacy,platelet aggregation rate and adverse reactions were recorded and compared. Results The effective rate of the observation group is 98.1%, significantly higher than the control group of78.18%（P〈0.05）; The platelet aggregation rate of the observation group is（25.1±3.0）%, significantly lower than the control group of（34.9±5.9）%（P〈0.05）; the dafference of data was statlcdly significant The adverse reactions of the observation group is 5.45 %, less than the control group of 7.27%, but there were no statistical significance（P〉0.05）. Conclusion There is significant clinical efficacy of high dose of clopidogrel on the interventional therapy for patients with UAP, and this application can better supress platelet aggregation rate and is more safe.